ENSMUSG00000021559


Mus musculus

Features
Gene ID: ENSMUSG00000021559
  
Biological name :Dapk1
  
Synonyms : Dapk1 / Death-associated protein kinase 1 / Q80YE7
  
Possible biological names infered from orthology : P53355
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B2
Gene start: 60601947
Gene end: 60763191
  
Corresponding Affymetrix probe sets: 10405693 (MoGene1.0st)   1426915_at (Mouse Genome 430 2.0 Array)   1427358_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040825
Ensembl peptide - ENSMUSP00000076666
Ensembl peptide - ENSMUSP00000153205
Ensembl peptide - ENSMUSP00000153607
NCBI entrez gene - 69635     See in Manteia.
MGI - MGI:1916885
RefSeq - XM_017315598
RefSeq - NM_001285917
RefSeq - NM_029653
RefSeq - NM_134062
RefSeq - XM_006517370
RefSeq - XM_006517371
RefSeq Peptide - NP_598823
RefSeq Peptide - NP_001272846
RefSeq Peptide - NP_083929
swissprot - Q80YE7
swissprot - A0A286YDD8
Ensembl - ENSMUSG00000021559
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapk1ENSDARG00000060093Danio rerio
 DAPK1ENSGALG00000012608Gallus gallus
 DAPK1ENSG00000196730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG0000003497418
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG0000003238016
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620715
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283612
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG0000002609410
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG000000449519
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG000000274709
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG000000316989


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR002110  Ankyrin repeat
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020676  Death-associated protein kinase 1
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0071346 cellular response to interferon-gamma IMP
 biological_processGO:0071447 cellular response to hydroperoxide ISO
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:2000310 regulation of NMDA receptor activity IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017075 syntaxin-1 binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dapk1tm1Akc/Dapk1tm1Akc
Genetic Background: B6.129X1-Dapk1tm1Akc

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: AtrxGt(E085A04)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rettm1.1Pern/Rettm1.1Pern
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: AtrxGt(E085A04)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: AtrxGt(E085A04)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: AtrxGt(E085A04)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rettm1.1Pern/Rettm1.1Pern
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011372 decreased renal tubule apoptosis "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Asy/a
Genetic Background: C57BL/6J-Asy/a/J

Allelic Composition: Dapk1tm1Akc/Dapk1tm1Akc
Genetic Background: B6.129X1-Dapk1tm1Akc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020099 Unc5b / Q8K1S3 / unc-5 netrin receptor B / Q8IZJ1*  / reaction / complex






 

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