ENSMUSG00000032380


Mus musculus

Features
Gene ID: ENSMUSG00000032380
  
Biological name :Dapk2
  
Synonyms : Dapk2 / Death-associated protein kinase 2 / Q8VDF3
  
Possible biological names infered from orthology : Q9UIK4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 66158223
Gene end: 66272242
  
Corresponding Affymetrix probe sets: 10586491 (MoGene1.0st)   1451453_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034944
Ensembl peptide - ENSMUSP00000117134
NCBI entrez gene - 13143     See in Manteia.
MGI - MGI:1341297
RefSeq - NM_010019
RefSeq - XM_006510811
RefSeq Peptide - NP_034149
swissprot - F6YX98
swissprot - Q8VDF3
Ensembl - ENSMUSG00000032380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapk2aENSDARG00000061096Danio rerio
 dapk2bENSDARG00000103666Danio rerio
 DAPK2ENSGALG00000003336Gallus gallus
 DAPK2ENSG00000035664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG0000002155962
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG0000003497461
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283637
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG0000002609434
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG0000004495134
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG0000003169834
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG0000002747029
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043276 anoikis IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1990266 neutrophil migration IMP
 biological_processGO:2000424 positive regulation of eosinophil chemotaxis IEA
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034423 autophagosome lumen IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0013025 increased Ly6C low monocyte number "increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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