ENSMUSG00000026094


Mus musculus

Features
Gene ID: ENSMUSG00000026094
  
Biological name :Stk17b
  
Synonyms : Q8BG48 / Serine/threonine-protein kinase 17B / Stk17b
  
Possible biological names infered from orthology : O94768 / serine/threonine kinase 17b
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.1
Gene start: 53755506
Gene end: 53785224
  
Corresponding Affymetrix probe sets: 10354588 (MoGene1.0st)   1423452_at (Mouse Genome 430 2.0 Array)   1430165_at (Mouse Genome 430 2.0 Array)   1450997_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139880
Ensembl peptide - ENSMUSP00000027263
NCBI entrez gene - 98267     See in Manteia.
MGI - MGI:2138162
RefSeq - NM_133810
RefSeq - XM_006496359
RefSeq Peptide - NP_598571
swissprot - A0A087WPR0
swissprot - Q8BG48
Ensembl - ENSMUSG00000026094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk17bENSDARG00000014348Danio rerio
 STK17BENSGALG00000007924Gallus gallus
 O94768ENSG00000081320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG0000002155937
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG0000003497436
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG0000003238034
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG0000002747031
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG0000004495130
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG0000003169830
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283630
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Stk17btm1Hed/Stk17btm1Hed
Genetic Background: B6.129X1-Stk17btm1Hed

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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