ENSMUSG00000034974


Mus musculus

Features
Gene ID: ENSMUSG00000034974
  
Biological name :Dapk3
  
Synonyms : Dapk3 / Death-associated protein kinase 3 / O54784
  
Possible biological names infered from orthology : O43293
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81183005
Gene end: 81193197
  
Corresponding Affymetrix probe sets: 10365005 (MoGene1.0st)   1423446_at (Mouse Genome 430 2.0 Array)   1456496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151499
Ensembl peptide - ENSMUSP00000151254
Ensembl peptide - ENSMUSP00000151577
Ensembl peptide - ENSMUSP00000151297
Ensembl peptide - ENSMUSP00000035962
Ensembl peptide - ENSMUSP00000137333
NCBI entrez gene - 13144     See in Manteia.
MGI - MGI:1203520
RefSeq - NM_007828
RefSeq - XM_006513195
RefSeq - XM_006513194
RefSeq - NM_001190473
RefSeq - NM_001190474
RefSeq Peptide - NP_001177402
RefSeq Peptide - NP_001177403
RefSeq Peptide - NP_031854
swissprot - A0A1W2P6K3
swissprot - O54784
swissprot - Q05A21
swissprot - A0A1W2P730
swissprot - A0A1W2P6J6
Ensembl - ENSMUSG00000034974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapk3ENSDARG00000074447Danio rerio
 DAPK3ENSGALG00000037733Gallus gallus
 DAPK3ENSG00000167657Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG0000002155957
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG0000003238050
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283632
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG0000002609430
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG0000003169829
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG0000004495127
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG0000002747026
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007346 regulation of mitotic cell cycle ISO
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043519 regulation of myosin II filament organization IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0051893 regulation of focal adhesion assembly ISO
 biological_processGO:0071346 cellular response to interferon-gamma IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0097190 apoptotic signaling pathway IGI
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISO
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043522 leucine zipper domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1.2Tmae/Picalm+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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