ENSMUSG00000022836


Mus musculus

Features
Gene ID: ENSMUSG00000022836
  
Biological name :Mylk
  
Synonyms : Mylk / myosin light chain kinase
  
Possible biological names infered from orthology : Q15746
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 34745210
Gene end: 35002420
  
Corresponding Affymetrix probe sets: 10435345 (MoGene1.0st)   1425504_at (Mouse Genome 430 2.0 Array)   1425505_at (Mouse Genome 430 2.0 Array)   1425506_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023538
NCBI entrez gene - 107589     See in Manteia.
MGI - MGI:894806
RefSeq - XM_017316849
RefSeq - NM_139300
RefSeq - XM_006521702
RefSeq - XM_006521703
RefSeq Peptide - NP_647461
swissprot - B1B1A8
Ensembl - ENSMUSG00000022836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylkaENSDARG00000034801Danio rerio
 mylkbENSDARG00000004753Danio rerio
 MYLKENSGALG00000011708Gallus gallus
 MYLKENSG00000065534Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620720
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG0000003169812
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG0000002747011
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG000000215599
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG000000449519
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG000000323807
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG000000349747
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG000000260946


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015725  Myosin Light Chain Kinase 1, Kinase domain
 IPR017441  Protein kinase, ATP binding site
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060414 aorta smooth muscle tissue morphogenesis IEA
 biological_processGO:0071476 cellular hypotonic response IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004687 myosin light chain kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mylktm1.1Bph/Mylktm1.1Bph
Genetic Background: involves: C57BL/6N

Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mylktm1.1Bph/Mylktm1.1Bph
Genetic Background: involves: C57BL/6N

Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl,Rpe65tm1Tmr/Rpe65tm1Tmr,Tyrc-2J/Tyrc-2J
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl,Rpe65tm1Tmr/Rpe65tm1Tmr,Tyrc-2J/Tyrc-2J
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl,Rpe65tm1Tmr/Rpe65tm1Tmr,Tyrc-2J/Tyrc-2J
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plin2tm1Itl/Plin2tm1Itl,Rpe65tm1Tmr/Rpe65tm1Tmr,Tyrc-2J/Tyrc-2J
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mylktm1.1Bph/Mylktm1.1Bph
Genetic Background: involves: C57BL/6N

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003289 abnormal intestinal peristalsis "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003622 incomplete emptying of bladder "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011082 abnormal gastrointestinal motility "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mylktm1.1Bph/Mylktm1.1Bph
Genetic Background: involves: C57BL/6N

Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mylktm1.1Bph/Mylktm1.1Bph
Genetic Background: involves: C57BL/6N

Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0011503 disdended jejunum "an expansion in the volume of the portion of the small intestine that extends from the duodenum to the ileum" [MGI:anna]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction






 

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