ENSGALG00000011708


Gallus gallus

Features
Gene ID: ENSGALG00000011708
  
Biological name :MYLK
  
Synonyms : Gallus gallus myosin light chain kinase (MYLK), transcript variant 1, mRNA. / MYLK
  
Possible biological names infered from orthology : myosin light chain kinase / Q15746
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 27324149
Gene end: 27507722
  
Corresponding Affymetrix probe sets: Gga.4091.1.S2_a_at (Chicken Array)   Gga.4091.2.S1_a_at (Chicken Array)   Gga.4091.3.S1_a_at (Chicken Array)   Gga.5108.1.S1_at (Chicken Array)   GgaAffx.7457.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037183
Ensembl peptide - ENSGALP00000061379
Ensembl peptide - ENSGALP00000019112
NCBI entrez gene - 396445     See in Manteia.
RefSeq - XM_015289793
RefSeq - NM_001322361
RefSeq - NM_205459
RefSeq Peptide - NP_990790
RefSeq Peptide - NP_001309290
swissprot - A0A1L1RRF3
swissprot - E1C906
swissprot - F1NQ78
Ensembl - ENSGALG00000011708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylkaENSDARG00000034801Danio rerio
 mylkbENSDARG00000004753Danio rerio
 MYLKENSG00000065534Homo sapiens
 MylkENSMUSG00000022836Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYLK3 / myosin light chain kinase 3 / Q32MK0* / Q3UIZ8*ENSGALG0000000433412
MYLK2 / myosin light chain kinase 2, skeletal/cardiac muscle / Q8VCR8* / Q9H1R3* / myosin light chain kinase 2*ENSGALG0000000627310
DAPK1 / death-associated protein kinase 1 isoform 1 / P53355* / Q80YE7* / death associated protein kinase 1*ENSGALG000000126089
ENSGALG000000008249
SPEG* / Q15772* / Q62407* / SPEG complex locus*ENSGALG000000431988
DAPK3 / death associated protein kinase 3 / O43293* / O54784*ENSGALG000000377338
MYLK4 / myosin light chain kinase family member 4 / Q86YV6*ENSGALG000000128458
DAPK2 / death associated protein kinase 2 / Q8VDF3* / Q9UIK4*ENSGALG000000033367
ENSGALG000000260706
STK17A / serine/threonine-protein kinase 17A / Q9UEE5* / serine/threonine kinase 17a*ENSGALG000000311176
STK17B / serine/threonine kinase 17b / O94768* / Q8BG48* / Serine/threonine-protein kinase 17B *ENSGALG000000079245
SPEG* / Q15772* / Q62407* / SPEG complex locus*ENSGALG000000369733


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015725  Myosin Light Chain Kinase 1, Kinase domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060414 aorta smooth muscle tissue morphogenesis IEA
 biological_processGO:0071476 cellular hypotonic response IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004687 myosin light chain kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000001793 MYL10 / myosin light chain 10 / Q62082* / Q9BUA6* / Myosin regulatory light chain 10 *  / reaction
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / reaction / complex
 ENSGALG00000038635 O14950* / Myl12a* / MYL12B* / Q3THE2* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSGALG00000035086 MYL6 / myosin light chain 6 / P60660* / Q60605* / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle*  / reaction
 ENSGALG00000014854 P24032 / MYL12A / Myosin regulatory light chain 2, smooth muscle minor isoform / Q3THE2* / MYL12B* / O14950* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction






 

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