ENSGALG00000006426


Gallus gallus

Features
Gene ID: ENSGALG00000006426
  
Biological name :PAK2
  
Synonyms : p21 (RAC1) activated kinase 2 / PAK2
  
Possible biological names infered from orthology : Q13177 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 4632558
Gene end: 4651108
  
Corresponding Affymetrix probe sets: Gga.7822.1.S1_at (Chicken Array)   GgaAffx.3992.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010358
Ensembl peptide - ENSGALP00000052294
Ensembl peptide - ENSGALP00000045977
NCBI entrez gene - 424860     See in Manteia.
RefSeq - XM_004936995
RefSeq - XM_422671
swissprot - E1BS97
swissprot - A0A1D5PHL4
swissprot - A0A1D5P006
Ensembl - ENSGALG00000006426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak2aENSDARG00000068177Danio rerio
 pak2bENSDARG00000018476Danio rerio
 PAK2ENSG00000180370Homo sapiens
 Pak2ENSMUSG00000022781Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*ENSGALG0000000068180
PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *ENSGALG0000000805877
PAK5 / p21 (RAC1) activated kinase 5 / Pak7* / Q8C015* / Q9P286* / Serine/threonine-protein kinase PAK 5 *ENSGALG0000000894738
PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSGALG0000003460535
PAK4 / p21 (RAC1) activated kinase 4 / O96013* / Q8BTW9* / Serine/threonine-protein kinase PAK 4 *ENSGALG0000003132835
TAOK1 / TAO kinase 1 / Q5F2E8* / Q7L7X3*ENSGALG0000000408224
TAOK3 / serine/threonine-protein kinase TAO3 / Q8BYC6* / Q9H2K8* / TAO kinase 3*ENSGALG0000000739622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000001264 PLXNA2 / plexin A2 / O75051* / P70207*  / complex / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / reaction / complex
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSGALG00000006520 MYH11 / P10587 / Myosin-11 / P35749* / myosin heavy chain 11*  / reaction
 ENSGALG00000031448 MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction
 ENSGALG00000017414 JUP / junction plakoglobin / P14923* / Q02257*  / reaction
 ENSGALG00000032349 CDH5 / Q8AYD0 / Cadherin-5 / P33151* / P55284*  / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000011708 MYLK / Gallus gallus myosin light chain kinase (MYLK), transcript variant 1, mRNA. / Q15746* / myosin light chain kinase*  / reaction
 ENSGALG00000038635 O14950* / Myl12a* / MYL12B* / Q3THE2* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSGALG00000006097 PLXNA1 / plexin A1 / P70206* / Q9UIW2*  / reaction / complex
 ENSGALG00000014854 P24032 / MYL12A / Myosin regulatory light chain 2, smooth muscle minor isoform / Q3THE2* / MYL12B* / O14950* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction
 ENSGALG00000001183 MYH10 / myosin heavy chain 10 / P35580* / Q61879* / Myosin-10 *  / reaction
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / reaction
 ENSGALG00000035086 MYL6 / myosin light chain 6 / P60660* / Q60605* / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle*  / reaction
 ENSGALG00000001076 LIMK1 / Q8QFP8 / LIM domain kinase 1 / P53667* / P53668*  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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