ENSGALG00000002113


Gallus gallus

Features
Gene ID: ENSGALG00000002113
  
Biological name :LCP2
  
Synonyms : LCP2 / lymphocyte cytosolic protein 2
  
Possible biological names infered from orthology : Q13094 / Q60787
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 3848537
Gene end: 3877852
  
Corresponding Affymetrix probe sets: Gga.236.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046177
Ensembl peptide - ENSGALP00000003296
NCBI entrez gene - 395438     See in Manteia.
RefSeq - NM_204701
RefSeq Peptide - NP_990032
swissprot - Q9DG07
swissprot - A0A1D5P0J9
Ensembl - ENSGALG00000002113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcp2aENSDARG00000055955Danio rerio
 LCP2ENSG00000043462Homo sapiens
 Lcp2ENSMUSG00000002699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BLNK / Q9YGC1 / B-cell linker protein / Q8WV28* / Q9QUN3* / B cell linker*ENSGALG0000000697319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045576 mast cell activation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0036398 TCR signalosome IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0023027 MHC class I protein binding, via antigen binding groove IDA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000001486 ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...  / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction / complex
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000014124 TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*  / complex
 ENSGALG00000003857 ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000003792 FYB / FYN-binding protein / FYB1* / O15117* / O35601* / FYN binding protein 1*  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction






 

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