ENSGALG00000004958


Gallus gallus

Features
Gene ID: ENSGALG00000004958
  
Biological name :BTK
  
Synonyms : Bruton tyrosine kinase / BTK
  
Possible biological names infered from orthology : P35991 / Q06187 / Tyrosine-protein kinase BTK
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 2042911
Gene end: 2053843
  
Corresponding Affymetrix probe sets: GgaAffx.11885.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045102
Ensembl peptide - ENSGALP00000062933
Ensembl peptide - ENSGALP00000050884
Ensembl peptide - ENSGALP00000007936
NCBI entrez gene - 374075     See in Manteia.
RefSeq - XM_015278172
RefSeq - XM_015278167
RefSeq - XM_015278168
RefSeq - XM_015278169
RefSeq - XM_015278170
RefSeq - XM_015278171
RefSeq - NM_204233
RefSeq - XM_015278163
RefSeq - XM_015278164
RefSeq - XM_015278165
RefSeq - XM_015278166
RefSeq Peptide - NP_989564
swissprot - A0A1L1RVS7
swissprot - A0A1D5PDN9
swissprot - A0A1D5NXK5
swissprot - Q5ZLF2
Ensembl - ENSGALG00000004958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 btkENSDARG00000004433Danio rerio
 BTKENSG00000010671Homo sapiens
 BtkENSMUSG00000031264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412451
ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSGALG0000000385747
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655744
TXK / TXK tyrosine kinase / P42681* / P42682*ENSGALG0000001412738
ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*ENSGALG0000000387527
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035726
FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSGALG0000000834024
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127023
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG0000000073619
FER / FER tyrosine kinase / P16591* / P70451* / Tyrosine-protein kinase Fer *ENSGALG0000000027313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0002344 B cell affinity maturation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0098761 cellular response to interleukin-7 IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000001486 ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...  / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction / complex
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction






 

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