ENSGALG00000039327


Gallus gallus

Features
Gene ID: ENSGALG00000039327
  
Biological name :VAV3
  
Synonyms : VAV3 / vav guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology : Q9R0C8 / Q9UKW4 / vav 3 oncogene
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 992070
Gene end: 1140063
  
Corresponding Affymetrix probe sets: Gga.2876.1.S1_a_at (Chicken Array)   Gga.2876.1.S2_a_at (Chicken Array)   Gga.2876.2.S1_x_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054725
NCBI entrez gene - 373939     See in Manteia.
RefSeq - XM_015290229
RefSeq - NM_206863
RefSeq - XM_015290227
RefSeq - XM_015290228
RefSeq Peptide - NP_996745
swissprot - Q8UUX6
Ensembl - ENSGALG00000039327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vav3bENSDARG00000075962Danio rerio
 VAV3ENSG00000134215Homo sapiens
 Vav3ENSMUSG00000033721Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG0000000269955
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462116
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600516
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584214
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235413
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219313
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG0000000643912
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467412
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760811
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG0000003100910
ENSGALG000000018945
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000980  SH2 domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003096  Smooth muscle protein/calponin
 IPR011993  PH-like domain superfamily
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR028530  Protein vav1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006906 vesicle fusion IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030031 cell projection assembly IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000001486 ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...  / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / reaction / complex
 ENSGALG00000003857 ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000014124 TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction / complex
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / complex / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / reaction / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000026995 RHOG / ras homolog family member G / P84095* / P84096*  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction






 

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