ENSGALG00000002699


Gallus gallus

Features
Gene ID: ENSGALG00000002699
  
Biological name :VAV2
  
Synonyms : guanine nucleotide exchange factor VAV2 / VAV2
  
Possible biological names infered from orthology : P52735 / Q60992 / vav 2 oncogene / vav guanine nucleotide exchange factor 2
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 7524633
Gene end: 7622902
  
Corresponding Affymetrix probe sets: Gga.4341.1.S1_at (Chicken Array)   Gga.4341.2.S1_at (Chicken Array)   Gga.4341.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044431
Ensembl peptide - ENSGALP00000004246
NCBI entrez gene - 373938     See in Manteia.
RefSeq - NM_204142
RefSeq Peptide - NP_989473
swissprot - F1NG51
swissprot - A0A1D5NVQ5
Ensembl - ENSGALG00000002699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vav2ENSDARG00000044718Danio rerio
 VAV2ENSG00000160293Homo sapiens
 Vav2ENSMUSG00000009621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG0000003932755
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462117
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600515
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235415
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584214
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219314
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467413
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG0000000643913
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760812
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG0000003100911
ENSGALG000000018945
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000980  SH2 domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR028530  Protein vav1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030031 cell projection assembly IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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