ENSMUSG00000009621


Mus musculus

Features
Gene ID: ENSMUSG00000009621
  
Biological name :Vav2
  
Synonyms : Q60992 / Vav2 / vav 2 oncogene
  
Possible biological names infered from orthology : P52735 / vav guanine nucleotide exchange factor 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 27262104
Gene end: 27427033
  
Corresponding Affymetrix probe sets: 10481210 (MoGene1.0st)   1421272_at (Mouse Genome 430 2.0 Array)   1435065_x_at (Mouse Genome 430 2.0 Array)   1435244_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062782
Ensembl peptide - ENSMUSP00000138964
NCBI entrez gene - 22325     See in Manteia.
MGI - MGI:102718
RefSeq - XM_017317167
RefSeq - NM_009500
RefSeq - XM_006497854
RefSeq - XM_006497856
RefSeq - XM_006497858
RefSeq Peptide - NP_033526
swissprot - Q60992
swissprot - Q7TSI6
Ensembl - ENSMUSG00000009621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vav2ENSDARG00000044718Danio rerio
 VAV2ENSGALG00000002699Gallus gallus
 VAV2ENSG00000160293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372154
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411651
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962117
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896016
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199014
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380014
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151113
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248913
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565612
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113312
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000980  SH2 domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR035732  VAV2 protein, second SH3 domain
 IPR035733  VAV2 protein, first SH3 domain
 IPR035880  VAV2, SH2 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IMP
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0030031 cell projection assembly IGI
 biological_processGO:0030032 lamellipodium assembly IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IGI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1Yai
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003184 increased ACE activity 
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005497 optic nerve cupping "concave shape of the nerve often as a result of the force of pressure from glaucoma" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005610 increased circulating antidiuretic hormone level "greater than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005662 increased circulating adrenaline level "greater than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005665 increased circulating noradrenaline level "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr,Vav3tm1Xrb/Vav3tm1Xrb
Genetic Background: involves: 129P2/OlaHsd

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008300 enlarged adrenal medulla "increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008301 adrenal medulla hyperplasia "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

 MP:0009812 abnormal bradykinin level "abnormal concentration of a potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: B6.129S-Vav2tm1Kdf Vav3tm1Swat

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / complex / reaction
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000073982 Rhog / P84096 / ras homolog family member G / P84095*  / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction






 

1 s.

 
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