ENSMUSG00000021457


Mus musculus

Features
Gene ID: ENSMUSG00000021457
  
Biological name :Syk
  
Synonyms : P48025 / spleen tyrosine kinase / Syk
  
Possible biological names infered from orthology : P43405 / spleen associated tyrosine kinase
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 52583173
Gene end: 52648792
  
Corresponding Affymetrix probe sets: 10405216 (MoGene1.0st)   1418261_at (Mouse Genome 430 2.0 Array)   1418262_at (Mouse Genome 430 2.0 Array)   1425797_a_at (Mouse Genome 430 2.0 Array)   1457239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060828
Ensembl peptide - ENSMUSP00000112914
Ensembl peptide - ENSMUSP00000113852
NCBI entrez gene - 20963     See in Manteia.
MGI - MGI:99515
RefSeq - XM_006516897
RefSeq - NM_001198977
RefSeq - NM_011518
RefSeq - XM_006516895
RefSeq - XM_006516896
RefSeq Peptide - NP_001185906
RefSeq Peptide - NP_035648
swissprot - P48025
swissprot - Q3UPF7
swissprot - E9PWE9
Ensembl - ENSMUSG00000021457
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sykENSDARG00000008186Danio rerio
 SYKENSGALG00000015216Gallus gallus
 SYKENSG00000165025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611754
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220927
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231224
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012224
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816624
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260722
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945621
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279119
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012234  Tyrosine-protein kinase, non-receptor SYK/ZAP-70
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR023420  Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
 IPR035838  SYK/ZAP-70, N-terminal SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001820 serotonin secretion IMP
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0002092 positive regulation of receptor internalization IMP
 biological_processGO:0002250 adaptive immune response ISS
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002283 neutrophil activation involved in immune response IMP
 biological_processGO:0002366 leukocyte activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002554 serotonin secretion by platelet IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion ISS
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0010543 regulation of platelet activation IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0019370 leukotriene biosynthetic process IMP
 biological_processGO:0030593 neutrophil chemotaxis ISS
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032928 regulation of superoxide anion generation IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042991 obsolete transcription factor import into nucleus ISO
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0043313 regulation of neutrophil degranulation IMP
 biological_processGO:0043366 beta selection IGI
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045401 positive regulation of interleukin-3 biosynthetic process IMP
 biological_processGO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IMP
 biological_processGO:0045579 positive regulation of B cell differentiation ISO
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IGI
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IGI
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071226 cellular response to molecule of fungal origin IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IDA
 biological_processGO:0090237 regulation of arachidonic acid secretion IMP
 biological_processGO:0090330 regulation of platelet aggregation IMP
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042101 T cell receptor complex ISO
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IDA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0042169 SH2 domain binding IDA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin alphaIIb beta3 signaling
Interleukin-2 signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Mgat5tm1Jwd/Mgat5tm1Jwd,Mgat5btm1.1Itl/Mgat5btm1.1Itl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000574 abnormal foot pad morphology "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/10 * CBA/Ca

Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/10 * CBA/Ca

Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Syktm1.1Tara/Syktm1.1Tara
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sellm2Btlr/Sellm2Btlr
Genetic Background: C57BL/6J-Sellm2Btlr

Allelic Composition: SykM2Btlr/Syk+
Genetic Background: C57BL/6J-SykM2Btlr

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/10 * CBA/Ca

Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Tie1-cre)9Ref/0,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc13a1tm1Mark/Slc13a1+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgat5tm1Jwd/Mgat5tm1Jwd,Mgat5btm1.1Itl/Mgat5btm1.1Itl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc13a1tm1Mark/Slc13a1+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc13a1tm1Mark/Slc13a1+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002869 increased insulin autoantibody level "elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004106 lymphatic vessel hyperplasia "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005020 abnormal late pro-B cell "anomalous structure, developoment, or number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
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Allelic Composition: Slc13a1tm1Mark/Slc13a1+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd,Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syktm1.1Tara/Syktm1.1Tara
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Sellm2Btlr/Sellm2Btlr
Genetic Background: C57BL/6J-Sellm2Btlr

Allelic Composition: SykM2Btlr/Syk+
Genetic Background: C57BL/6J-SykM2Btlr

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Slc13a1tm1Mark/Slc13a1+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0010195 abnormal lymphatic vessel endothelium morphology "any structural anomaly of the thin layer of flat cells that line the lymphatic vessels and form a barrier between circulating lymph in the lumen and the rest of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1.1Nns/Syktm1.1Nns,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0010198 decreased lymphatic vessel endothelial cell number "reduced number of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010200 enlarged lymphatic vessel "increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Syktm1.1Tara/Syktm1.1Tara
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003379 Cd79a / P11911 / B-cell antigen receptor complex-associated protein alpha chain / P11912* / CD79a molecule*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000023992 Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*  / complex / reaction
 ENSMUSG00000024680 Ms4a2 / P20490 / membrane-spanning 4-domains, subfamily A, member 2 / Q01362* / membrane spanning 4-domains A2*  / reaction / complex
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000030159 Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*  / reaction / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000028583 Pdpn / Q62011 / Podoplanin / Q86YL7*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction / complex
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000040592 Cd79b / P15530 / B-cell antigen receptor complex-associated protein beta chain / P40259* / CD79b molecule*  / complex / reaction
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000030165 Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / complex / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000005339 Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / reaction / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex / reaction
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000078810 Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*  / complex / reaction
 ENSMUSG00000079293 Clec7a / Q6QLQ4 / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q9BXN2* / C-type lectin domain containing 7A*  / complex






 

1 s.

 
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