ENSMUSG00000022791


Mus musculus

Features
Gene ID: ENSMUSG00000022791
  
Biological name :Tnk2
  
Synonyms : Tnk2 / tyrosine kinase, non-receptor, 2
  
Possible biological names infered from orthology : Q07912
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 32643874
Gene end: 32683493
  
Corresponding Affymetrix probe sets: 10435094 (MoGene1.0st)   1448297_a_at (Mouse Genome 430 2.0 Array)   1448298_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110774
Ensembl peptide - ENSMUSP00000110773
Ensembl peptide - ENSMUSP00000110775
Ensembl peptide - ENSMUSP00000152549
Ensembl peptide - ENSMUSP00000152338
Ensembl peptide - ENSMUSP00000129382
Ensembl peptide - ENSMUSP00000125905
Ensembl peptide - ENSMUSP00000110779
Ensembl peptide - ENSMUSP00000110778
Ensembl peptide - ENSMUSP00000110777
Ensembl peptide - ENSMUSP00000110776
NCBI entrez gene - 51789     See in Manteia.
MGI - MGI:1858308
RefSeq - XM_017317066
RefSeq - XM_006522332
RefSeq - XM_006522333
RefSeq - XM_006522334
RefSeq - XM_006522335
RefSeq - XM_006522336
RefSeq - XM_006522337
RefSeq - XM_006522338
RefSeq - XM_006522339
RefSeq - XM_006522340
RefSeq - XM_006522342
RefSeq - XM_006522343
RefSeq - XM_006522344
RefSeq - XM_006522345
RefSeq - XM_011245946
RefSeq - XM_017317065
RefSeq - NM_001110147
RefSeq - NM_001289443
RefSeq - NM_001347185
RefSeq - NM_016788
RefSeq Peptide - NP_001334114
RefSeq Peptide - NP_058068
RefSeq Peptide - NP_001276372
RefSeq Peptide - NP_001103617
swissprot - D3Z3U7
swissprot - D3Z3U6
swissprot - D3Z3U5
swissprot - E9QN61
swissprot - G3X9X7
swissprot - A0A1Y7VJA6
swissprot - A0A0R4J1L0
swissprot - A0A1Y7VLM9
swissprot - E9QN60
swissprot - E9Q5M1
swissprot - E9PWA3
Ensembl - ENSMUSG00000022791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnk2aENSDARG00000090646Danio rerio
 tnk2bENSDARG00000104409Danio rerio
 TNK2ENSGALG00000027983Gallus gallus
 TNK2ENSG00000061938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158325
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231216
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260716
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012216
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220916
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816615
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945614
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611712
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015116  Cdc42 binding domain-like
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021619  Mig-6 domain
 IPR030220  Activated CDC42 kinase 1
 IPR036028  SH3-like domain superfamily
 IPR037085  Cdc42 binding domain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0070436 Grb2-EGFR complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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