ENSMUSG00000059456


Mus musculus

Features
Gene ID: ENSMUSG00000059456
  
Biological name :Ptk2b
  
Synonyms : Ptk2b / PTK2 protein tyrosine kinase 2 beta / Q9QVP9
  
Possible biological names infered from orthology : protein tyrosine kinase 2 beta / Q14289
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 66153257
Gene end: 66281052
  
Corresponding Affymetrix probe sets: 10420957 (MoGene1.0st)   1434653_at (Mouse Genome 430 2.0 Array)   1442927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086661
Ensembl peptide - ENSMUSP00000122683
Ensembl peptide - ENSMUSP00000137008
Ensembl peptide - ENSMUSP00000022622
Ensembl peptide - ENSMUSP00000106750
NCBI entrez gene - 19229     See in Manteia.
MGI - MGI:104908
RefSeq - XM_017315930
RefSeq - NM_001162366
RefSeq - NM_172498
RefSeq - XM_006518726
RefSeq - XM_011244994
RefSeq - XM_017315926
RefSeq - XM_017315927
RefSeq - XM_017315928
RefSeq - XM_017315929
RefSeq - NM_001162365
RefSeq Peptide - NP_001155837
RefSeq Peptide - NP_001155838
RefSeq Peptide - NP_766086
swissprot - Q9QVP9
swissprot - K7QD41
swissprot - E9Q2A6
swissprot - F7CCX1
swissprot - Q3UDE9
Ensembl - ENSMUSG00000059456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk2baENSDARG00000022841Danio rerio
 ptk2bbENSDARG00000039577Danio rerio
 PTK2BENSGALG00000016564Gallus gallus
 PTK2BENSG00000120899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260746
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220920
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012220
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231219
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816617
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279115
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158314
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611713
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030610  Protein-tyrosine kinase 2-beta
 IPR035963  FERM superfamily, second domain
 IPR036137  Focal adhesion kinase, targeting (FAT) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISS
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002688 regulation of leukocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006968 cellular defense response ISS
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway ISS
 biological_processGO:0007172 signal complex assembly IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0010752 regulation of cGMP-mediated signaling IMP
 biological_processGO:0010758 regulation of macrophage chemotaxis IMP
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IBA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 biological_processGO:0030826 obsolete regulation of cGMP biosynthetic process IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032960 regulation of inositol trisphosphate biosynthetic process IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway ISS
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation ISS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042976 activation of Janus kinase activity ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043267 negative regulation of potassium ion transport ISO
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045428 regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation ISO
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050848 regulation of calcium-mediated signaling IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071300 cellular response to retinoic acid ISO
 biological_processGO:0071498 cellular response to fluid shear stress IMP
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process ISO
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000538 positive regulation of B cell chemotaxis IMP
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex ISS
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097440 apical dendrite ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity ISS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004972 NMDA glutamate receptor activity ISS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043423 3-phosphoinositide-dependent protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction / complex
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000055447 Cd47 / Q61735 / Leukocyte surface antigen CD47 / Q08722* / CD47 molecule*  / reaction / complex






 

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