Manteia

ENSDARG00000022841

Danio rerio

Features

Gene ID:	ENSDARG00000022841

Biological name :	ptk2ba

Synonyms :	protein tyrosine kinase 2 beta, a / ptk2ba

Possible biological names infered from orthology :	protein tyrosine kinase 2 beta / PTK2B / PTK2 protein tyrosine kinase 2 beta / Q14289 / Q9QVP9

Species:	Danio rerio

Chr. number:	17
Strand:	-1
Band:
Gene start:	6113680
Gene end:	6202816

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000126522 Ensembl peptide - ENSDARP00000036466 Ensembl peptide - ENSDARP00000154978 NCBI entrez gene - 557258 See in Manteia. RefSeq - XM_005158579 RefSeq - XM_005158577 RefSeq - XM_021467276 swissprot - K7DYJ3 swissprot - E7FCB4 ZFIN ID - ZDB-GENE-080207-1 Ensembl - ENSDARG00000022841

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PTK2B	ENSGALG00000016564	Gallus gallus
PTK2B	ENSG00000120899	Homo sapiens
Ptk2b	ENSMUSG00000059456	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000039577	67
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000004672	47
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000100456	37
si:ch73-383l1.1	ENSDARG00000090408	19
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *	ENSDARG00000026294	18
erbb4a / erb-b2 receptor tyrosine kinase 4a	ENSDARG00000063207	18
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000036993	18
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000104409	16
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000006202	16
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000090646	16
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	ENSDARG00000008186	15
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *	ENSDARG00000069433	13
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*	ENSDARG00000015752	13
erbb4b / erb-b2 receptor tyrosine kinase 4b	ENSDARG00000089536	13
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...	ENSDARG00000013847	5
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*	ENSDARG00000056909	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR000299	FERM domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR005189	Focal adhesion kinase, targeting (FAT) domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR017441	Protein kinase, ATP binding site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR029071	Ubiquitin-like domain superfamily
IPR030610	Protein-tyrosine kinase 2-beta

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IBA
biological_process	GO:0002688	regulation of leukocyte chemotaxis	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007010	cytoskeleton organization	IBA
biological_process	GO:0007155	cell adhesion	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007172	signal complex assembly	IEA
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0030155	regulation of cell adhesion	IBA
biological_process	GO:0030334	regulation of cell migration	IEA
biological_process	GO:0030500	regulation of bone mineralization	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0042127	regulation of cell proliferation	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IBA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045765	regulation of angiogenesis	IEA
biological_process	GO:2000249	regulation of actin cytoskeleton reorganization	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005925	focal adhesion	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	IEA
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

VEGFA-VEGFR2 Pathway

Interleukin-2 signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr