ENSDARG00000036993


Danio rerio

Features
Gene ID: ENSDARG00000036993
  
Biological name :erbb3b
  
Synonyms : erb-b2 receptor tyrosine kinase 3b / erbb3b
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 3 / ERBB3 / P21860 / Q61526 / Receptor tyrosine-protein kinase erbB-3
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 25232411
Gene end: 25287666
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000116216
Ensembl peptide - ENSDARP00000105384
NCBI entrez gene - 100149258     See in Manteia.
NCBI entrez gene - 544664     See in Manteia.
RefSeq - NM_001128819
RefSeq - NM_001014826
RefSeq Peptide - NP_001014826
RefSeq Peptide - NP_001122291
swissprot - F1QP50
swissprot - E9QC99
ZFIN ID - ZDB-GENE-050107-1
Ensembl - ENSDARG00000036993
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERBB3ENSGALG00000033510Gallus gallus
 ERBB3ENSG00000065361Homo sapiens
 Erbb3ENSMUSG00000018166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000000620250
si:ch73-383l1.1ENSDARG0000009040838
erbb4a / erb-b2 receptor tyrosine kinase 4aENSDARG0000006320737
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *ENSDARG0000002629433
erbb4b / erb-b2 receptor tyrosine kinase 4bENSDARG0000008953631
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...ENSDARG0000001384719
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSDARG0000005690918
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000003957713
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000000467213
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000002284112
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000010045611
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000009064611
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000010440911
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*ENSDARG0000001575210
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*ENSDARG0000000818610
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *ENSDARG000000694339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001964 startle response IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0008347 glial cell migration IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048882 lateral line development IMP
 biological_processGO:0048914 myelination of anterior lateral line nerve axons IMP
 biological_processGO:0048932 myelination of posterior lateral line nerve axons IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000142 peripheral nervous system peripheral nervous system has fewer parts of type myelinating Schwann cell , abnormal
Show

 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve defasciculated , abnormal
posterior lateral line nerve has extra parts of type posterior lateral line neuromast , abnormal
posterior lateral line nerve has fewer parts of type glial cell , abnormal
posterior lateral line nerve sodium channel complex asymmetrical , abnormal
posterior lateral line nerve sodium channel complex elongated , abnormal
posterior lateral line nerve sodium channel complex undistributed , abnormal
posterior lateral line nerve sodium channel complex decreased amount , abnormal
posterior lateral line nerve mislocalised , abnormal
posterior lateral line nerve axon decreased amount , abnormal
posterior lateral line nerve myelin sheath absent , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion absent , abnormal
dorsal root ganglion neuron absent , abnormal
dorsal root ganglion decreased amount , abnormal
Show

 ZFA:0000243 neuromast neuromast quality , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast increased amount , abnormal
Show

 ZFA:0001115 trunk trunk melanophore stripe has fewer parts of type melanocyte , abnormal
trunk has extra parts of type posterior lateral line neuromast , abnormal
Show

 ZFA:0001117 post-vent region post-vent region melanophore stripe has fewer parts of type melanocyte , abnormal
post-vent region melanophore stripe decreased pigmentation , abnormal
post-vent region melanocyte poorly differentiated , abnormal
Show

 ZFA:0001270 blastema blastema decreased size , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe irregular spatial pattern , abnormal
Show

 ZFA:0001469 lateral line lateral line glial cell (sensu Vertebrata) disorganized , abnormal
lateral line quality , abnormal
Show

 ZFA:0001556 sympathetic chain ganglion sympathetic chain ganglion absent , abnormal
Show

 ZFA:0001576 sympathetic nervous system sympathetic nervous system neuron absent , abnormal
Show

 ZFA:0009052 motor neuron motor neuron has fewer parts of type myelinating Schwann cell , abnormal
Show

 ZFA:0009073 glial cell glial cell decreased amount , abnormal
glial cell absent , abnormal
glial cell morphology , abnormal
glial cell disorganized , abnormal
glial cell decreased thickness , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte quality , abnormal
melanocyte spatial pattern , abnormal
melanocyte melanoma increased occurrence , abnormal
Show

 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell morphology , abnormal
myelinating Schwann cell absent , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
neural crest cell position , abnormal
Show

 ZFA:0009198 xanthophore xanthophore decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr