ENSGALG00000033510


Gallus gallus

Features
Gene ID: ENSGALG00000033510
  
Biological name :ERBB3
  
Synonyms : ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 3 / P21860 / Q61526 / Receptor tyrosine-protein kinase erbB-3
  
Species: Gallus gallus
  
Chr. number: 33
Strand: 1
Band:
Gene start: 646832
Gene end: 664492
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000051173
Ensembl peptide - ENSGALP00000057012
NCBI entrez gene - 693245     See in Manteia.
RefSeq - NM_001044669
RefSeq - XM_015300273
RefSeq Peptide - NP_001038134
swissprot - A0A1D5PVN7
swissprot - A0A1D5PEH0
Ensembl - ENSGALG00000033510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbb3aENSDARG00000006202Danio rerio
 erbb3bENSDARG00000036993Danio rerio
 ERBB3ENSG00000065361Homo sapiens
 Erbb3ENSMUSG00000018166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312646
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808939
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152938
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174113
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656413
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798312
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521612
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014037 Schwann cell differentiation IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021545 cranial nerve development IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0055025 positive regulation of cardiac muscle tissue development IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0038132 neuregulin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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