ENSDARG00000006202


Danio rerio

Features
Gene ID: ENSDARG00000006202
  
Biological name :erbb3a
  
Synonyms : erb-b2 receptor tyrosine kinase 3a / erbb3a
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 3 / ERBB3 / P21860 / Q61526 / Receptor tyrosine-protein kinase erbB-3
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 7466223
Gene end: 7531427
  
Corresponding Affymetrix probe sets: Dr.26076.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000124007
Ensembl peptide - ENSDARP00000124619
Ensembl peptide - ENSDARP00000002603
NCBI entrez gene - 386635     See in Manteia.
RefSeq - NM_001005320
RefSeq Peptide - NP_001005320
swissprot - F8W2T0
swissprot - F1QSK6
swissprot - F8W3W7
ZFIN ID - ZDB-GENE-030916-3
Ensembl - ENSDARG00000006202
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERBB3ENSGALG00000033510Gallus gallus
 ERBB3ENSG00000065361Homo sapiens
 Erbb3ENSMUSG00000018166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSDARG0000003699354
si:ch73-383l1.1ENSDARG0000009040840
erbb4a / erb-b2 receptor tyrosine kinase 4aENSDARG0000006320739
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *ENSDARG0000002629434
erbb4b / erb-b2 receptor tyrosine kinase 4bENSDARG0000008953632
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...ENSDARG0000001384719
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSDARG0000005690919
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000000467213
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000002284112
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*ENSDARG0000003957712
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSDARG0000010045611
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000009064611
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*ENSDARG0000010440911
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*ENSDARG0000000818610
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *ENSDARG000000694339
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*ENSDARG000000157529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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