ENSMUSG00000018166


Mus musculus

Features
Gene ID: ENSMUSG00000018166
  
Biological name :Erbb3
  
Synonyms : Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 3 / P21860
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128567523
Gene end: 128589652
  
Corresponding Affymetrix probe sets: 10373467 (MoGene1.0st)   1434606_at (Mouse Genome 430 2.0 Array)   1452482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080716
NCBI entrez gene - 13867     See in Manteia.
MGI - MGI:95411
RefSeq - NM_010153
RefSeq Peptide - NP_034283
swissprot - Q61526
Ensembl - ENSMUSG00000018166
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbb3aENSDARG00000006202Danio rerio
 erbb3bENSDARG00000036993Danio rerio
 ERBB3ENSGALG00000033510Gallus gallus
 ERBB3ENSG00000065361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220946
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012238
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231238
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945613
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279112
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260712
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145711
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611711
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISO
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021545 cranial nerve development IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0055025 positive regulation of cardiac muscle tissue development IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IGI
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0038132 neuregulin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000300 thin endocardial cushion "reduced thickness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: C57BL/10ScSn-Dmdmdx/J

 MP:0000645 absent adrenergic chromaffin cells "missing cells responsible for epinephrine and norepinephrine secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:54931]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000844 abnormal pontine flexure "malformation or absence of the bend in the developing neural tube that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and medulla oblongata in the embryo" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000856 abnormal cerebellar plate morphology "malformed embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000865 absent vermis "missing narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C3H/He * C57BL/6

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001007 abnormal sympathetic system morphology "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Erbb3m3329Ddg/Erbb3tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb3m3329Ddg/Erbb3tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001105 abnormal PNS glia "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001108 absent Schwann cells "missing cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001109 absent Schwann cell precursors "missing progenitors of cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002200 abnormal brain ventricle/choroid plexus morphology "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C3H/He * C57BL/6

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004203 abnormal cranial flexure "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [J:10730, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm1Mal/Foxp3tm1Mal,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006046 atrioventricular valve insufficiency "the atrioventricular valves do not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0008316 abnormal prevertebral ganglion morphology "any structural anomaly of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008317 abnormal paravertebral ganglion morphology "any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

Allelic Composition: Erbb3m3329Ddg/Erbb3tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C3H/He * C57BL/6

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0009798 abnormal ophthalmic nerve morphology "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

 MP:0009800 abnormal mandibular nerve morphology "any structural anomaly of the motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3+,Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3+,Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm1.1Dwt
Genetic Background: either: 129S6/SvEvTac-Erbb3tm1.1Dwt or B6.129S6-Erbb3tm1.1Dwt

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Erbb3tm1Cbm/Erbb3tm1Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb3tm1Squ/Erbb3tm1Squ,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Erbb3m3329Ddg/Erbb3m3329Ddg
Genetic Background: involves: C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm1.1Dwt
Genetic Background: either: 129S6/SvEvTac-Erbb3tm1.1Dwt or B6.129S6-Erbb3tm1.1Dwt

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
Genetic Background: FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex
 ENSMUSG00000025373 Rnf41 / Q8BH75 / E3 ubiquitin-protein ligase NRDP1 / Q9H4P4* / ring finger protein 41*  / reaction / complex
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex






 

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