ENSMUSG00000025373


Mus musculus

Features
Gene ID: ENSMUSG00000025373
  
Biological name :Rnf41
  
Synonyms : E3 ubiquitin-protein ligase NRDP1 / Q8BH75 / Rnf41
  
Possible biological names infered from orthology : Q9H4P4 / ring finger protein 41
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128411657
Gene end: 128441441
  
Corresponding Affymetrix probe sets: 10367337 (MoGene1.0st)   1423842_a_at (Mouse Genome 430 2.0 Array)   1432003_a_at (Mouse Genome 430 2.0 Array)   1453633_a_at (Mouse Genome 430 2.0 Array)   1455763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151889
Ensembl peptide - ENSMUSP00000100869
Ensembl peptide - ENSMUSP00000132751
Ensembl peptide - ENSMUSP00000151260
NCBI entrez gene - 67588     See in Manteia.
MGI - MGI:1914838
RefSeq - NM_001164237
RefSeq - NM_026259
RefSeq Peptide - NP_001157709
RefSeq Peptide - NP_080535
swissprot - A0A1W2P811
swissprot - Q8BH75
Ensembl - ENSMUSG00000025373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf41ENSDARG00000036831Danio rerio
 RNF41ENSGALG00000032819Gallus gallus
 RNF41ENSG00000181852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CQ29 / Rnf151 / RING finger protein 151 / Q2KHN1*ENSMUSG0000000848218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015036  E3 ubiquitin-protein ligase NRDP1
 IPR017907  Zinc finger, RING-type, conserved site
 IPR037255  NRDP1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010498 proteasomal protein catabolic process ISO
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0030336 negative regulation of cell migration ISO
 biological_processGO:0043408 regulation of MAPK cascade ISO
 biological_processGO:0045619 regulation of lymphocyte differentiation IDA
 biological_processGO:0045637 regulation of myeloid cell differentiation IDA
 biological_processGO:0045732 positive regulation of protein catabolic process ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0051896 regulation of protein kinase B signaling ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 biological_processGO:1901525 negative regulation of mitophagy IGI
 biological_processGO:2000114 regulation of establishment of cell polarity IDA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0071782 endoplasmic reticulum tubular network ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005128 erythropoietin receptor binding IDA
 molecular_functionGO:0005135 interleukin-3 receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2:ERBB3 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / reaction / complex
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / reaction / complex






 

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