ENSG00000181852


Homo sapiens

Features
Gene ID: ENSG00000181852
  
Biological name :RNF41
  
Synonyms : Q9H4P4 / ring finger protein 41 / RNF41
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56202175
Gene end: 56221933
  
Corresponding Affymetrix probe sets: 201961_s_at (Human Genome U133 Plus 2.0 Array)   201962_s_at (Human Genome U133 Plus 2.0 Array)   235459_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450164
Ensembl peptide - ENSP00000484671
Ensembl peptide - ENSP00000342755
Ensembl peptide - ENSP00000377581
Ensembl peptide - ENSP00000446595
Ensembl peptide - ENSP00000447303
Ensembl peptide - ENSP00000448187
Ensembl peptide - ENSP00000448330
Ensembl peptide - ENSP00000449575
NCBI entrez gene - 10193     See in Manteia.
RefSeq - XM_011537735
RefSeq - NM_001242826
RefSeq - NM_005785
RefSeq - NM_194358
RefSeq - NM_194359
RefSeq - XM_005268561
RefSeq - XM_011537734
RefSeq Peptide - NP_919340
RefSeq Peptide - NP_001229755
RefSeq Peptide - NP_005776
RefSeq Peptide - NP_919339
swissprot - F8VVY2
swissprot - F8VNZ6
swissprot - F8VSB6
swissprot - F8VSE5
swissprot - Q9H4P4
swissprot - A0A024RB33
swissprot - F8VSP7
Ensembl - ENSG00000181852
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf41ENSDARG00000036831Danio rerio
 RNF41ENSGALG00000032819Gallus gallus
 Rnf41ENSMUSG00000025373Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2KHN1 / RNF151 / ring finger protein 151ENSG0000017958017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015036  E3 ubiquitin-protein ligase NRDP1
 IPR017907  Zinc finger, RING-type, conserved site
 IPR037255  NRDP1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010498 proteasomal protein catabolic process IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0043408 regulation of MAPK cascade IDA
 biological_processGO:0045619 regulation of lymphocyte differentiation IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0051896 regulation of protein kinase B signaling IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:1901525 negative regulation of mitophagy IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005128 erythropoietin receptor binding IEA
 molecular_functionGO:0005135 interleukin-3 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2:ERBB3 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction / complex
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction






 

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