ENSG00000158458


Homo sapiens

Features
Gene ID: ENSG00000158458
  
Biological name :NRG2
  
Synonyms : neuregulin 2 / NRG2 / O14511
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.2
Gene start: 139846779
Gene end: 140043299
  
Corresponding Affymetrix probe sets: 206879_s_at (Human Genome U133 Plus 2.0 Array)   208062_s_at (Human Genome U133 Plus 2.0 Array)   242303_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444235
Ensembl peptide - ENSP00000354910
Ensembl peptide - ENSP00000367483
Ensembl peptide - ENSP00000289409
Ensembl peptide - ENSP00000289422
Ensembl peptide - ENSP00000342660
Ensembl peptide - ENSP00000351323
NCBI entrez gene - 9542     See in Manteia.
OMIM - 603818
RefSeq - XM_017010066
RefSeq - NM_001184935
RefSeq - NM_004883
RefSeq - NM_013981
RefSeq - NM_013982
RefSeq - NM_013983
RefSeq - XM_005268533
RefSeq - XM_006714810
RefSeq - XM_017010064
RefSeq - XM_017010065
RefSeq Peptide - NP_001171864
RefSeq Peptide - NP_053584
RefSeq Peptide - NP_053585
RefSeq Peptide - NP_053586
RefSeq Peptide - NP_004874
swissprot - O14511
swissprot - F5GZS7
Ensembl - ENSG00000158458
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg2aENSDARG00000077818Danio rerio
 nrg2bENSDARG00000086585Danio rerio
 NRG2ENSGALG00000033641Gallus gallus
 Nrg2ENSMUSG00000060275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRG1 / Q02297 / neuregulin 1ENSG0000015716826
NRG3 / P56975 / neuregulin 3ENSG0000018573711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048513 animal organ development IBA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction / complex
 ENSG00000124882 EREG / O14944 / epiregulin  / complex / reaction
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000007264 MATK / P42679 / megakaryocyte-associated tyrosine kinase  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction / complex
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex
 ENSG00000162959 MEMO1 / Q9Y316 / mediator of cell motility 1  / complex / reaction
 ENSG00000131504 DIAPH1 / O60610 / diaphanous related formin 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000181852 RNF41 / Q9H4P4 / ring finger protein 41  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / reaction / complex
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / complex / reaction






 

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