ENSG00000185737


Homo sapiens

Features
Gene ID: ENSG00000185737
  
Biological name :NRG3
  
Synonyms : neuregulin 3 / NRG3 / P56975
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.1
Gene start: 81875314
Gene end: 82987179
  
Corresponding Affymetrix probe sets: 229233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385804
Ensembl peptide - ENSP00000384796
Ensembl peptide - ENSP00000440377
Ensembl peptide - ENSP00000473669
Ensembl peptide - ENSP00000451858
Ensembl peptide - ENSP00000451376
Ensembl peptide - ENSP00000441201
Ensembl peptide - ENSP00000361214
Ensembl peptide - ENSP00000361215
NCBI entrez gene - 10718     See in Manteia.
OMIM - 605533
RefSeq - XM_017015583
RefSeq - XM_017015573
RefSeq - XM_017015574
RefSeq - XM_017015575
RefSeq - XM_017015576
RefSeq - XM_017015577
RefSeq - XM_017015578
RefSeq - XM_017015579
RefSeq - XM_017015580
RefSeq - XM_017015581
RefSeq - XM_017015582
RefSeq - NM_001010848
RefSeq - NM_001165972
RefSeq - NM_001165973
RefSeq - XM_005269444
RefSeq - XM_011539172
RefSeq - XM_011539173
RefSeq - XM_011539175
RefSeq - XM_011539178
RefSeq Peptide - NP_001010848
RefSeq Peptide - NP_001159444
RefSeq Peptide - NP_001159445
swissprot - D9ZHQ3
swissprot - P56975
swissprot - D9ZHQ8
swissprot - D9ZHP6
swissprot - R4GNI6
swissprot - D9ZHQ7
swissprot - D9ZHQ6
Ensembl - ENSG00000185737
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg3bENSDARG00000089766Danio rerio
 NRG3ENSGALG00000042812Gallus gallus
 Nrg3ENSMUSG00000041014Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRG2 / O14511 / neuregulin 2ENSG0000015845814
NRG1 / Q02297 / neuregulin 1ENSG0000015716813


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048513 animal organ development IBA
 biological_processGO:0060596 mammary placode formation IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0008083 growth factor activity NAS
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity NAS
 molecular_functionGO:0030971 receptor tyrosine kinase binding NAS
 molecular_functionGO:0045499 chemorepellent activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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