ENSMUSG00000041014


Mus musculus

Features
Gene ID: ENSMUSG00000041014
  
Biological name :Nrg3
  
Synonyms : Nrg3 / O35181 / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3
  
Possible biological names infered from orthology : neuregulin 3 / P56975
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 38368952
Gene end: 39473088
  
Corresponding Affymetrix probe sets: 10419049 (MoGene1.0st)   1421017_at (Mouse Genome 430 2.0 Array)   1460289_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129783
Ensembl peptide - ENSMUSP00000134727
Ensembl peptide - ENSMUSP00000136884
NCBI entrez gene - 18183     See in Manteia.
MGI - MGI:1097165
RefSeq - XM_017315912
RefSeq - XM_006518685
RefSeq - XM_006518686
RefSeq - XM_006518687
RefSeq - XM_011244987
RefSeq - XM_017315910
RefSeq - XM_017315911
RefSeq - NM_001190187
RefSeq - NM_001190188
RefSeq - NM_008734
RefSeq Peptide - NP_032760
RefSeq Peptide - NP_001177116
RefSeq Peptide - NP_001177117
swissprot - G3V023
swissprot - O35181
swissprot - E9Q396
Ensembl - ENSMUSG00000041014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg3bENSDARG00000089766Danio rerio
 NRG3ENSGALG00000042812Gallus gallus
 NRG3ENSG00000185737Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrg1 / neuregulin 1 / Q02297*ENSMUSG0000006299115
Nrg2 / neuregulin 2 / O14511*ENSMUSG0000006027513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0060596 mammary placode formation IMP
 biological_processGO:2001223 negative regulation of neuron migration IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0045499 chemorepellent activity IDA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0000629 absent mammary gland "missing milk-secreting glands of the breast" [J:18378]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009720 abnormal mammary gland pattern "aberration in the number of mammary glands that differentiate during early embryogenesis as it relates to the norm for the species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009721 supernumerary mammary glands "more than the expected number of mammary glands differentiate during early embryogenesis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009722 abnormal nipple development "an anomaly in the differentiation of the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009723 supernumerary nipples "differentiation of more than the normal number of structures located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009724 ectopic nipples "abnormal location of structures normally located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0009741 ectopic mammary gland "one or more of the expected number of mammary glands that differentiate during early embryogenesis is/ are not located according to the normal arrangement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr