ENSMUSG00000062991


Mus musculus

Features
Gene ID: ENSMUSG00000062991
  
Biological name :Nrg1
  
Synonyms : neuregulin 1 / Nrg1
  
Possible biological names infered from orthology : Q02297
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A3
Gene start: 31814551
Gene end: 32884029
  
Corresponding Affymetrix probe sets: 10578045 (MoGene1.0st)   10578066 (MoGene1.0st)   1456524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146403
Ensembl peptide - ENSMUSP00000146375
Ensembl peptide - ENSMUSP00000146456
Ensembl peptide - ENSMUSP00000147156
Ensembl peptide - ENSMUSP00000147121
Ensembl peptide - ENSMUSP00000146905
Ensembl peptide - ENSMUSP00000146857
Ensembl peptide - ENSMUSP00000146842
Ensembl peptide - ENSMUSP00000146816
Ensembl peptide - ENSMUSP00000146617
Ensembl peptide - ENSMUSP00000146507
Ensembl peptide - ENSMUSP00000146478
Ensembl peptide - ENSMUSP00000073546
NCBI entrez gene - 211323     See in Manteia.
MGI - MGI:96083
RefSeq - XM_017312641
RefSeq - XM_006509068
RefSeq - XM_006509069
RefSeq - XM_006509072
RefSeq - XM_006509076
RefSeq - XM_006509077
RefSeq - XM_006509078
RefSeq - XM_006509080
RefSeq - XM_006509081
RefSeq - XM_011242133
RefSeq - XM_017312636
RefSeq - XM_017312637
RefSeq - XM_017312638
RefSeq - XM_017312639
RefSeq - XM_017312640
RefSeq - NM_178591
RefSeq - XM_006509059
RefSeq - XM_006509060
RefSeq - XM_006509061
RefSeq - XM_006509062
RefSeq - XM_006509063
RefSeq - XM_006509064
RefSeq - XM_006509065
RefSeq - XM_006509066
RefSeq - XM_006509067
RefSeq Peptide - NP_848706
swissprot - A0A140LJ88
swissprot - A0A140LIP8
swissprot - A0A140LIK5
swissprot - A0A140LIJ3
swissprot - A0A140LIG9
swissprot - A0A140LHZ9
swissprot - A0A140LHQ6
swissprot - A0A140LHN1
swissprot - A0A140LHG5
swissprot - A0A140LHD8
swissprot - Q6DR98
swissprot - A0A140LJC1
swissprot - Q6DR99
Ensembl - ENSMUSG00000062991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg1ENSDARG00000104314Danio rerio
 NRG1ENSGALG00000015422Gallus gallus
 NRG1ENSG00000157168Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrg2 / neuregulin 2 / O14511*ENSMUSG0000006027531
Nrg3 / O35181 / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3 / P56975* / neuregulin 3*ENSMUSG0000004101415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018250  Neuregulin-1
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0001964 startle response IMP
 biological_processGO:0003161 cardiac conduction system development IDA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008366 axon ensheathment IMP
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IGI
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0021781 glial cell fate commitment IDA
 biological_processGO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0038129 ERBB3 signaling pathway IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043624 cellular protein complex disassembly ISO
 biological_processGO:0045213 neurotransmitter receptor metabolic process IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IDA
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048738 cardiac muscle tissue development IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060379 cardiac muscle cell myoblast differentiation IEA
 biological_processGO:0060956 endocardial cell differentiation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IGI
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IGI
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 biological_processGO:2001223 negative regulation of neuron migration IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030673 axolemma IDA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0003712 transcription coregulator activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005176 ErbB-2 class receptor binding IGI
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0043125 ErbB-3 class receptor binding IEA
 molecular_functionGO:0045499 chemorepellent activity IDA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000299 failure of endocardial cushion closure "failure of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [J:29971]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nrg1tm1Lwr/Nrg1+
Genetic Background: involves: 129/Sv

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001066 absent trigeminal nerve "missing chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001067 absent mandibular nerve "missing third division of the trigeminal nerve " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001068 abnormal mandibular nerve branching "malformed or misprojected axons of the mandibular nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0001080 defasiculated phrenic nerve "misprojection or failure to bundle motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001084 abnormal petrosal ganglion morphology "malformation of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001101 abnormal superior vagus ganglion morphology "malformation of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001108 absent Schwann cells "missing cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: involves: 129/Sv

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1m1Yzcm/Nrg1m1Yzcm
Genetic Background: C57BL/6J-Nrg1m1Yzcm

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nrg1tm2Zhou/Nrg1tm2Zhou
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nrg1tm1Gne/Nrg1tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Nrg1tm3Cbm/Nrg1tm3Cbm,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Nrg1tm4Cbm/Nrg1tm4.1Cbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001506 limp posture "lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csn1s1tm1Afk/Csn1s1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrg1m1Yzcm/Nrg1m1Yzcm
Genetic Background: C57BL/6J-Nrg1m1Yzcm

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Nrg1tm2Zhou/Nrg1tm2Zhou
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Gne/Nrg1tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Nrg1tm4Cbm/Nrg1tm4.1Cbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J

Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Nrg1tm4.1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6

Allelic Composition: Nrg1tm3Cbm/Nrg1tm3Cbm,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004075 reduced Schwann cell precursor number "fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Fil/Gpc3+
Genetic Background: B6.Cg-Gpc3tm1Fil

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Nrg1tm4Cbm/Nrg1tm4.1Cbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J

Allelic Composition: Nrg1tm4.1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Nrg1tm4.1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6

Allelic Composition: Nrg1tm3Cbm/Nrg1tm3Cbm,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: 129/Sv-Nrg1tm1Lwr

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm1Leth/Nrg1tm1Leth
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm1Zhou/Nrg1tm1Zhou
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Zhou/Nrg1tm2Zhou
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nrg1m1Yzcm/Nrg1m1Yzcm
Genetic Background: C57BL/6J-Nrg1m1Yzcm

 MP:0014119 abnormal mandibular nerve innervation pattern "any changes in the placement, morphology or number of mandibular nerve fibers providing motor and sensory nerve supply from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini" [ISBN:0683400088]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020388 decreased radial glial cell number "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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