ENSDARG00000104314


Danio rerio

Features
Gene ID: ENSDARG00000104314
  
Biological name :nrg1
  
Synonyms : neuregulin 1 / nrg1
  
Possible biological names infered from orthology : Q02297
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 7284121
Gene end: 7472359
  
Corresponding Affymetrix probe sets: Dr.12258.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000131493
Ensembl peptide - ENSDARP00000137540
Ensembl peptide - ENSDARP00000134846
Ensembl peptide - ENSDARP00000132985
Ensembl peptide - ENSDARP00000132632
NCBI entrez gene - 796461     See in Manteia.
RefSeq - XM_009300563
RefSeq - NM_001044911
RefSeq - NM_001277084
RefSeq - NM_001277085
RefSeq Peptide - NP_001264014
RefSeq Peptide - NP_001038376
RefSeq Peptide - NP_001264013
swissprot - B3DK99
swissprot - A0A0R4IPH3
swissprot - A0A0R4IFE6
swissprot - A0A0R4IDP7
swissprot - A0A0R4IBM0
ZFIN ID - ZDB-GENE-050302-113
Ensembl - ENSDARG00000104314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRG1ENSGALG00000015422Gallus gallus
 NRG1ENSG00000157168Homo sapiens
 Nrg1ENSMUSG00000062991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrg2b / neuregulin 2b / NRG2* / O14511* / neuregulin 2*ENSDARG0000008658531
nrg2a / neuregulin 2a / NRG2* / O14511* / neuregulin 2*ENSDARG0000007781822
nrg3b / neuregulin 3b / NRG3* / O35181* / P56975* / neuregulin 3* / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3*ENSDARG0000008976614
CR749775.2ENSDARG000001171057


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018250  Neuregulin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IGI
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021755 eurydendroid cell differentiation IMP
 biological_processGO:0021778 oligodendrocyte cell fate specification IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0036135 Schwann cell migration IMP
 biological_processGO:0048699 generation of neurons IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain oligodendrocyte decreased amount , abnormal
Show

 ZFA:0000034 lateral line system lateral line system has extra parts of type posterior lateral line neuromast , abnormal
Show

 ZFA:0000100 cerebellum cerebellum eurydendroid cell decreased amount , abnormal
Show

 ZFA:0000114 heart heart increased amount , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve lacks parts or has fewer parts of type myelinating Schwann cell , abnormal
posterior lateral line nerve lateral to epidermis basement membrane, abnormal
posterior lateral line nerve defasciculated , abnormal
posterior lateral line nerve located in epidermis , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion neuron mislocalised , abnormal
dorsal root ganglion neuron decreased amount , abnormal
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 ZFA:0000243 neuromast neuromast increased amount , abnormal
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 ZFA:0000445 optic tectum optic tectum generation of neurons decreased process quality , abnormal
optic tectum mitotic cell cycle process decreased process quality , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast increased amount , abnormal
Show

 ZFA:0005073 atrioventricular ring atrioventricular ring amount , ameliorated
atrioventricular ring position , ameliorated
Show

 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell absent , abnormal
myelinating Schwann cell decreased amount , abnormal
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 ZFA:0009365 interneuromast cell interneuromast cell Notch signaling pathway increased process quality , abnormal
interneuromast cell fibroblast growth factor receptor signaling pathway increased process quality , abnormal
interneuromast cell canonical Wnt signaling pathway increased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr