ENSDARG00000077818


Danio rerio

Features
Gene ID: ENSDARG00000077818
  
Biological name :nrg2a
  
Synonyms : neuregulin 2a / nrg2a
  
Possible biological names infered from orthology : neuregulin 2 / NRG2 / O14511
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 28554716
Gene end: 28737321
  
Corresponding Affymetrix probe sets: Dr.17701.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000106092
Ensembl peptide - ENSDARP00000112183
Ensembl peptide - ENSDARP00000109319
Ensembl peptide - ENSDARP00000089467
NCBI entrez gene - 100006951     See in Manteia.
RefSeq - NM_001099254
RefSeq Peptide - NP_001092724
swissprot - F1QC20
swissprot - F1QKE1
swissprot - F1RCA4
swissprot - B9VQL4
swissprot - A5D6U9
ZFIN ID - ZDB-GENE-070615-10
Ensembl - ENSDARG00000077818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRG2ENSGALG00000033641Gallus gallus
 NRG2ENSG00000158458Homo sapiens
 Nrg2ENSMUSG00000060275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrg2b / neuregulin 2b / NRG2* / O14511* / neuregulin 2*ENSDARG0000008658560
nrg1 / neuregulin 1 / Q02297*ENSDARG0000010431433
nrg3b / neuregulin 3b / NRG3* / O35181* / P56975* / neuregulin 3* / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3*ENSDARG0000008976615
CR749775.2ENSDARG0000011710512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IGI
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0098773 skin epidermis development IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold morphology , abnormal
median fin fold anatomical margin increased thickness , abnormal
median fin fold anatomical margin protruding , abnormal
Show

 ZFA:0000089 fin fold actinotrichium fin fold actinotrichium increased thickness , abnormal
fin fold actinotrichium bent , abnormal
fin fold actinotrichium mislocalised , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion neuron mislocalised , abnormal
dorsal root ganglion neuron decreased amount , abnormal
dorsal root ganglion neuron absent , abnormal
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 ZFA:0000717 apical ectodermal ridge median fin fold apical ectodermal ridge median fin fold cell morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0001614 atrial endocardium atrial endocardium decreased amount , abnormal
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 ZFA:0001615 ventricular endocardium ventricular endocardium decreased amount , abnormal
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 ZFA:0005317 pectoral fin fold pectoral fin fold morphology , abnormal
pectoral fin fold anatomical margin increased thickness , abnormal
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 ZFA:0009165 neural crest cell neural crest cell position , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell apical-basal polarity , abnormal
cardiac muscle cell apical constriction decreased occurrence , abnormal
cardiac muscle cell apical plasma membrane spatial pattern , abnormal
cardiac muscle cell decreased amount , abnormal
cardiac muscle cell Notch signaling pathway decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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