ENSGALG00000033641


Gallus gallus

Features
Gene ID: ENSGALG00000033641
  
Biological name :NRG2
  
Synonyms : neuregulin 2 / NRG2
  
Possible biological names infered from orthology : O14511
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 1242064
Gene end: 1393985
  
Corresponding Affymetrix probe sets: GgaAffx.605.2.S1_s_at (Chicken Array)   GgaAffx.605.3.S1_at (Chicken Array)   GgaAffx.605.4.S1_at (Chicken Array)   GgaAffx.605.5.S1_at (Chicken Array)   GgaAffx.605.5.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047635
Ensembl peptide - ENSGALP00000057015
NCBI entrez gene - 427606     See in Manteia.
RefSeq - XM_015293544
RefSeq - XM_015293545
RefSeq - XM_015293546
RefSeq - XM_015293547
swissprot - A0A1D5PVP0
swissprot - A0A1D5P4M3
Ensembl - ENSGALG00000033641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg2aENSDARG00000077818Danio rerio
 nrg2bENSDARG00000086585Danio rerio
 NRG2ENSG00000158458Homo sapiens
 Nrg2ENSMUSG00000060275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*ENSGALG0000001542231
NRG3 / neuregulin 3 / O35181* / P56975* / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3*ENSGALG0000004281211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction / complex
 ENSGALG00000010624 MEMO1 / mediator of cell motility 1 / Q91VH6* / Q9Y316* / Protein MEMO1 *  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex
 ENSGALG00000000736 MATK / megakaryocyte-associated tyrosine kinase / P42679*  / complex / reaction
 ENSGALG00000032819 RNF41 / ring finger protein 41 / Q8BH75* / Q9H4P4* / E3 ubiquitin-protein ligase NRDP1 *  / reaction / complex
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction






 

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