ENSGALG00000014773


Gallus gallus

Features
Gene ID: ENSGALG00000014773
  
Biological name :ERBIN
  
Synonyms : erbb2 interacting protein / ERBIN
  
Possible biological names infered from orthology : Q80TH2 / Q96RT1
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 20753850
Gene end: 20841105
  
Corresponding Affymetrix probe sets: Gga.12553.1.S1_s_at (Chicken Array)   GgaAffx.24516.1.S1_s_at (Chicken Array)   GgaAffx.24516.2.S1_s_at (Chicken Array)   GgaAffx.24516.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023789
Ensembl peptide - ENSGALP00000046926
NCBI entrez gene - 431583     See in Manteia.
RefSeq - XM_015277611
RefSeq - XM_015277609
RefSeq - XM_015277610
RefSeq - XM_004937291
RefSeq - XM_015277606
RefSeq - XM_015277607
RefSeq - XM_015277608
swissprot - E1BZY4
swissprot - A0A1D5P2M9
Ensembl - ENSGALG00000014773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbinENSDARG00000044281Danio rerio
 ERBINENSG00000112851Homo sapiens
 ErbinENSMUSG00000021709Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC7 / leucine rich repeat containing 7 / Q96NW7*ENSGALG0000001128442
SCRIB / scribbled planar cell polarity protein / Q14160* / Q80U72*ENSGALG0000003279019
LRRC1 / leucine rich repeat containing 1 / Q80VQ1* / Q9BTT6* / Leucine-rich repeat-containing protein 1 *ENSGALG0000001630415
MFHAS1 / malignant fibrous histiocytoma amplified sequence 1 / Q3V1N1* / Q9Y4C4* / Malignant fibrous histiocytoma-amplified sequence 1 homolog *ENSGALG0000001144412
SHOC2 / leucine-rich repeat protein SHOC-2 / O88520* / Q9UQ13* / SHOC2, leucine rich repeat scaffold protein* / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), trans...ENSGALG0000000877110
LRRC40 / leucine-rich repeat-containing protein 40 / Q9H9A6* / leucine rich repeat containing 40* / leucine-rich repeat-containing protein 40 isoform b *ENSGALG000000113019
LRRIQ4 / leucine rich repeats and IQ motif containing 4 / A6H6A4* / A6NIV6* / Leucine-rich repeat and IQ domain-containing protein 4 *ENSGALG000000093979
ENSGALG000000443135
ENSGALG000000437605
LRRC30 / leucine rich repeat containing 30 / A6NM36*ENSGALG000000426524
LRRC10 / leucine rich repeat containing 10 / Q5BKY1* / Q8K3W2* / Leucine-rich repeat-containing protein 10 *ENSGALG000000099764


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030056 hemidesmosome IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005176 ErbB-2 class receptor binding IEA
 molecular_functionGO:0005178 integrin binding IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction






 

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