ENSG00000112851


Homo sapiens

Features
Gene ID: ENSG00000112851
  
Biological name :ERBIN
  
Synonyms : erbb2 interacting protein / ERBIN / Q96RT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q12.3
Gene start: 65926475
Gene end: 66082549
  
Corresponding Affymetrix probe sets: 217941_s_at (Human Genome U133 Plus 2.0 Array)   222473_s_at (Human Genome U133 Plus 2.0 Array)   232896_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425728
Ensembl peptide - ENSP00000423959
Ensembl peptide - ENSP00000426632
Ensembl peptide - ENSP00000284037
Ensembl peptide - ENSP00000370322
Ensembl peptide - ENSP00000370325
Ensembl peptide - ENSP00000370330
Ensembl peptide - ENSP00000397833
Ensembl peptide - ENSP00000422015
Ensembl peptide - ENSP00000422766
NCBI entrez gene - 55914     See in Manteia.
OMIM - 606944
RefSeq - XM_017009637
RefSeq - NM_001253697
RefSeq - NM_001253698
RefSeq - NM_001253699
RefSeq - NM_001253701
RefSeq - NM_018695
RefSeq - XM_005248554
RefSeq - XM_005248555
RefSeq - XM_006714660
RefSeq - XM_017009635
RefSeq - XM_017009636
RefSeq - NM_001006600
RefSeq Peptide - NP_001240626
RefSeq Peptide - NP_001240628
RefSeq Peptide - NP_001240630
RefSeq Peptide - NP_061165
RefSeq Peptide - NP_001006600
RefSeq Peptide - NP_001240627
swissprot - H0YA04
swissprot - H0Y9E8
swissprot - Q96RT1
swissprot - B4DIP2
Ensembl - ENSG00000112851
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbinENSDARG00000044281Danio rerio
 ERBINENSGALG00000014773Gallus gallus
 ErbinENSMUSG00000021709Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC7 / Q96NW7 / leucine rich repeat containing 7ENSG0000003312242
SCRIB / Q14160 / scribbled planar cell polarity proteinENSG0000018090024
LRRC1 / Q9BTT6 / leucine rich repeat containing 1ENSG0000013726915
MFHAS1 / Q9Y4C4 / malignant fibrous histiocytoma amplified sequence 1ENSG0000014732412
LRRD1 / A4D1F6 / leucine rich repeats and death domain containing 1ENSG0000024072011
A6NIV6 / LRRIQ4 / leucine rich repeats and IQ motif containing 4ENSG0000018830610
SHOC2 / Q9UQ13 / SHOC2, leucine rich repeat scaffold proteinENSG0000010806110
LRRC40 / Q9H9A6 / leucine rich repeat containing 40ENSG000000665579
LRRC10 / Q5BKY1 / leucine rich repeat containing 10ENSG000001988125
A6NIK2 / LRRC10B / leucine rich repeat containing 10BENSG000002049505
A6NM36 / LRRC30 / leucine rich repeat containing 30ENSG000002064224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032927  Erbin
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007229 integrin-mediated signaling pathway NAS
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032495 response to muramyl dipeptide IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0045104 intermediate filament cytoskeleton organization NAS
 biological_processGO:0045175 basal protein localization NAS
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity NAS
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IEA
 cellular_componentGO:0005604 basement membrane TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009925 basal plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030056 hemidesmosome IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005176 ErbB-2 class receptor binding TAS
 molecular_functionGO:0005200 structural constituent of cytoskeleton NAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / complex / reaction
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction / complex






 

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