ENSG00000180900


Homo sapiens

Features
Gene ID: ENSG00000180900
  
Biological name :SCRIB
  
Synonyms : Q14160 / SCRIB / scribbled planar cell polarity protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 143790920
Gene end: 143815379
  
Corresponding Affymetrix probe sets: 212556_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349486
Ensembl peptide - ENSP00000322938
Ensembl peptide - ENSP00000431519
Ensembl peptide - ENSP00000433546
Ensembl peptide - ENSP00000366756
NCBI entrez gene - 23513     See in Manteia.
OMIM - 607733
RefSeq - NM_182706
RefSeq - NM_015356
RefSeq Peptide - NP_056171
RefSeq Peptide - NP_874365
swissprot - Q14160
swissprot - H0YCG0
swissprot - H0YDF9
Ensembl - ENSG00000180900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scribENSDARG00000000861Danio rerio
 SCRIBENSGALG00000032790Gallus gallus
 ScribENSMUSG00000022568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC7 / Q96NW7 / leucine rich repeat containing 7ENSG0000003312221
ERBIN / Q96RT1 / erbb2 interacting proteinENSG0000011285120
LRRC1 / Q9BTT6 / leucine rich repeat containing 1ENSG0000013726920
MFHAS1 / Q9Y4C4 / malignant fibrous histiocytoma amplified sequence 1ENSG0000014732412
LRRD1 / A4D1F6 / leucine rich repeats and death domain containing 1ENSG000002407209
SHOC2 / Q9UQ13 / SHOC2, leucine rich repeat scaffold proteinENSG000001080619
A6NIV6 / LRRIQ4 / leucine rich repeats and IQ motif containing 4ENSG000001883068
LRRC40 / Q9H9A6 / leucine rich repeat containing 40ENSG000000665578
LRRC10 / Q5BKY1 / leucine rich repeat containing 10ENSG000001988125
A6NIK2 / LRRC10B / leucine rich repeat containing 10BENSG000002049505
A6NM36 / LRRC30 / leucine rich repeat containing 30ENSG000002064224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001921 positive regulation of receptor recycling IMP
 biological_processGO:0002093 auditory receptor cell morphogenesis IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016080 synaptic vesicle targeting IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021747 cochlear nucleus development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030683 evasion or tolerance by virus of host immune response IEA
 biological_processGO:0035089 establishment of apical/basal cell polarity IMP
 biological_processGO:0039502 suppression by virus of host type I interferon-mediated signaling pathway IEA
 biological_processGO:0039503 suppression by virus of host innate immune response IEA
 biological_processGO:0039563 suppression by virus of host STAT1 activity IEA
 biological_processGO:0039564 suppression by virus of host STAT2 activity IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0043615 astrocyte cell migration IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0050918 positive chemotaxis IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IMP
 biological_processGO:0060603 mammary gland duct morphogenesis ISS
 biological_processGO:0071896 protein localization to adherens junction IMP
 biological_processGO:0090630 activation of GTPase activity IMP
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0098609 cell-cell adhesion IGI
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
 biological_processGO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0034750 Scrib-APC-beta-catenin complex IDA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104290 FZD3 / Q9NPG1 / frizzled class receptor 3  / reaction / complex
 ENSG00000162738 Q9ULK5 / VANGL2 / VANGL planar cell polarity protein 2  / complex / reaction






 

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