ENSMUSG00000022568


Mus musculus

Features
Gene ID: ENSMUSG00000022568
  
Biological name :Scrib
  
Synonyms : Q80U72 / Scrib / scribbled planar cell polarity protein
  
Possible biological names infered from orthology : Q14160
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76047158
Gene end: 76069784
  
Corresponding Affymetrix probe sets: 10429699 (MoGene1.0st)   1427064_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002603
Ensembl peptide - ENSMUSP00000105572
Ensembl peptide - ENSMUSP00000114573
Ensembl peptide - ENSMUSP00000115329
Ensembl peptide - ENSMUSP00000068056
NCBI entrez gene - 105782     See in Manteia.
MGI - MGI:2145950
RefSeq - XM_017316355
RefSeq - NM_001310543
RefSeq - NM_134089
RefSeq - XM_006520238
RefSeq - XM_006520239
RefSeq - XM_006520242
RefSeq - XM_017316354
RefSeq - NM_001310542
RefSeq Peptide - NP_598850
RefSeq Peptide - NP_001297471
RefSeq Peptide - NP_001297472
swissprot - D3YVA3
swissprot - Q80U72
swissprot - D3YU97
Ensembl - ENSMUSG00000022568
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scribENSDARG00000000861Danio rerio
 SCRIBENSGALG00000032790Gallus gallus
 SCRIBENSG00000180900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*ENSMUSG0000002170920
Lrrc7 / leucine rich repeat containing 7 / Q96NW7*ENSMUSG0000002817620
Lrrc1 / Q80VQ1 / Leucine-rich repeat-containing protein 1 / Q9BTT6* / leucine rich repeat containing 1*ENSMUSG0000003235220
Mfhas1 / Q3V1N1 / Malignant fibrous histiocytoma-amplified sequence 1 homolog / Q9Y4C4* / malignant fibrous histiocytoma amplified sequence 1*ENSMUSG0000007005612
Shoc2 / O88520 / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA. / Q9UQ13* / SHOC2, leucine rich repeat scaffold protein*ENSMUSG000000249769
Lrrd1 / Q8C0R9 / Leucine-rich repeat and death domain-containing protein 1 / A4D1F6* / leucine rich repeats and death domain containing 1*ENSMUSG000000403679
Lrrc40 / leucine-rich repeat-containing protein 40 isoform b / Q9H9A6* / leucine rich repeat containing 40*ENSMUSG000000630528
A6H6A4 / Lrriq4 / Leucine-rich repeat and IQ domain-containing protein 4 / A6NIV6* / leucine rich repeats and IQ motif containing 4*ENSMUSG000000277038
Lrrc10 / Q8K3W2 / Leucine-rich repeat-containing protein 10 / Q5BKY1* / leucine rich repeat containing 10*ENSMUSG000000601875
Lrrc10b / leucine rich repeat containing 10B / A6NIK2*ENSMUSG000000902915
Lrrc30 / leucine rich repeat containing 30 / A6NM36*ENSMUSG000000733754


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure ISO
 biological_processGO:0001921 positive regulation of receptor recycling ISO
 biological_processGO:0002093 auditory receptor cell morphogenesis IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0016080 synaptic vesicle targeting IMP
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021747 cochlear nucleus development IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035089 establishment of apical/basal cell polarity ISO
 biological_processGO:0042060 wound healing IGI
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0043615 astrocyte cell migration IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISS
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IMP
 biological_processGO:0050918 positive chemotaxis IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IGI
 biological_processGO:0060561 apoptotic process involved in morphogenesis ISS
 biological_processGO:0060603 mammary gland duct morphogenesis IMP
 biological_processGO:0071896 protein localization to adherens junction ISO
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0098609 cell-cell adhesion ISS
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
 biological_processGO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0031252 cell leading edge ISO
 cellular_componentGO:0034750 Scrib-APC-beta-catenin complex ISO
 cellular_componentGO:0035748 myelin sheath abaxonal region IDA
 cellular_componentGO:0042734 presynaptic membrane ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Scribm51206BHubr/Scrib+,Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Cntn1m1J/Cntn1m1J
Genetic Background: B6;C-Cntn1m1J/GrsrJ

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C57BL/6J * NMRI

Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: C3H.Cg-ScribCrc

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scrib+
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scrib+
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: ScribCrc/Scrib+
Genetic Background: involves: C57BL/6J * NMRI

Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cntn1m1J/Cntn1m1J
Genetic Background: B6;C-Cntn1m1J/GrsrJ

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C57BL/6J * NMRI

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C57BL/6J * NMRI

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Scribm51206BHubr/Scrib+,Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribm51206BHubr/Scrib+,Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribm51206BHubr/Scrib+,Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribcrn2/Scribcrn2
Genetic Background: involves: A/J * FVB/N

 MP:0004961 increased prostate weight "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scrib+
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scrib+
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005382 craniofacial phenotype 
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005651 abnormal gonad rudiment morphology "absence or structural anomaly of the undifferentiated mesoderm that gives rise to the gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+
Genetic Background: involves: 129S4/SvJae

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Scribtm1.2Phum/Scrib+
Genetic Background: involves: FVB/N

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: BALB/c * C57BL/6 * CBA/CaJ * NMRI

Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C57BL/6J * NMRI

Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: C3H.Cg-ScribCrc

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cntn1m1J/Cntn1m1J
Genetic Background: B6;C-Cntn1m1J/GrsrJ

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scribtm1.1Phum,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: 129S4/SvJae * FVB/NCrl

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0009770 abnormal optic chiasm morphology "an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Scribtm1.1Phum/Scrib+
Genetic Background: involves: 129S4/SvJae

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribm51206BHubr/Scribm51206BHubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C57BL/6J * NMRI

Allelic Composition: Scribtm1.2Phum/Scribtm1.2Phum
Genetic Background: involves: FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+
Genetic Background: (AKR/J x C57BL/6J-ApcMin)F1

 MP:0011964 increased total retina thickness "increased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scrib+
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012679 absent third ventricle "absence of the narrow cleft located inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MGI:anna]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0013765 iris hyperplasia "overdevelopment or increased size of the iris, usually due to an increased number of cells" [MGI:Anna]
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Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007989 Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*  / complex / reaction
 ENSMUSG00000026556 Q91ZD4 / Vangl2 / VANGL planar cell polarity 2 / Q9ULK5* / VANGL planar cell polarity protein 2*  / complex / reaction






 

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