ENSMUSG00000024976


Mus musculus

Features
Gene ID: ENSMUSG00000024976
  
Biological name :Shoc2
  
Synonyms : Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA. / O88520 / Shoc2
  
Possible biological names infered from orthology : Q9UQ13 / SHOC2, leucine rich repeat scaffold protein
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53944306
Gene end: 54033268
  
Corresponding Affymetrix probe sets: 10464015 (MoGene1.0st)   1423129_at (Mouse Genome 430 2.0 Array)   1425845_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025932
Ensembl peptide - ENSMUSP00000127932
NCBI entrez gene - 56392     See in Manteia.
MGI - MGI:1927197
RefSeq - XM_017318260
RefSeq - NM_001168505
RefSeq - NM_001355242
RefSeq - NM_019658
RefSeq - XM_006527228
RefSeq - XM_011247299
RefSeq Peptide - NP_001161977
RefSeq Peptide - NP_001342171
RefSeq Peptide - NP_062632
swissprot - O88520
Ensembl - ENSMUSG00000024976
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shoc2ENSDARG00000040853Danio rerio
 SHOC2ENSGALG00000008771Gallus gallus
 SHOC2ENSG00000108061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scrib / Q80U72 / scribbled planar cell polarity protein / Q14160*ENSMUSG0000002256827
Lrrc7 / leucine rich repeat containing 7 / Q96NW7*ENSMUSG0000002817625
Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*ENSMUSG0000002170925
Lrrc40 / leucine-rich repeat-containing protein 40 isoform b / Q9H9A6* / leucine rich repeat containing 40*ENSMUSG0000006305223
Lrrd1 / Q8C0R9 / Leucine-rich repeat and death domain-containing protein 1 / A4D1F6* / leucine rich repeats and death domain containing 1*ENSMUSG0000004036722
Mfhas1 / Q3V1N1 / Malignant fibrous histiocytoma-amplified sequence 1 homolog / Q9Y4C4* / malignant fibrous histiocytoma amplified sequence 1*ENSMUSG0000007005621
Lrrc1 / Q80VQ1 / Leucine-rich repeat-containing protein 1 / Q9BTT6* / leucine rich repeat containing 1*ENSMUSG0000003235221
A6H6A4 / Lrriq4 / Leucine-rich repeat and IQ domain-containing protein 4 / A6NIV6* / leucine rich repeats and IQ motif containing 4*ENSMUSG0000002770320
Lrrc30 / leucine rich repeat containing 30 / A6NM36*ENSMUSG0000007337513
Lrrc10b / leucine rich repeat containing 10B / A6NIK2*ENSMUSG0000009029112
Lrrc10 / Q8K3W2 / Leucine-rich repeat-containing protein 10 / Q5BKY1* / leucine rich repeat containing 10*ENSMUSG0000006018710


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007265 Ras protein signal transduction IBA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IBA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Igf1tm1.1Nros/Igf1tm1.1Nros
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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