ENSMUSG00000028176


Mus musculus

Features
Gene ID: ENSMUSG00000028176
  
Biological name :Lrrc7
  
Synonyms : leucine rich repeat containing 7 / Lrrc7
  
Possible biological names infered from orthology : Q96NW7
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H4
Gene start: 158082891
Gene end: 158562221
  
Corresponding Affymetrix probe sets: 10503054 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000142440
Ensembl peptide - ENSMUSP00000143365
Ensembl peptide - ENSMUSP00000142498
Ensembl peptide - ENSMUSP00000101659
NCBI entrez gene - 242274     See in Manteia.
MGI - MGI:2676665
RefSeq - XM_017319582
RefSeq - XM_006501508
RefSeq - XM_006501510
RefSeq - XM_006501511
RefSeq - XM_006501512
RefSeq - XM_006501514
RefSeq - XM_011240122
RefSeq - XM_011240123
RefSeq - NM_001081358
RefSeq - NM_001291452
RefSeq - NM_001291453
RefSeq - XM_006501502
RefSeq - XM_006501504
RefSeq - XM_006501505
RefSeq - XM_006501506
RefSeq - XM_006501507
RefSeq Peptide - NP_001278381
RefSeq Peptide - NP_001278382
RefSeq Peptide - NP_001074827
swissprot - E9Q6L9
swissprot - A0A0G2JDT9
swissprot - B9EHV0
swissprot - A0A0G2JFZ5
Ensembl - ENSMUSG00000028176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc7ENSDARG00000079670Danio rerio
 LRRC7ENSGALG00000011284Gallus gallus
 LRRC7ENSG00000033122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*ENSMUSG0000002170939
Scrib / Q80U72 / scribbled planar cell polarity protein / Q14160*ENSMUSG0000002256823
Lrrc1 / Q80VQ1 / Leucine-rich repeat-containing protein 1 / Q9BTT6* / leucine rich repeat containing 1*ENSMUSG0000003235214
Mfhas1 / Q3V1N1 / Malignant fibrous histiocytoma-amplified sequence 1 homolog / Q9Y4C4* / malignant fibrous histiocytoma amplified sequence 1*ENSMUSG0000007005612
Lrrd1 / Q8C0R9 / Leucine-rich repeat and death domain-containing protein 1 / A4D1F6* / leucine rich repeats and death domain containing 1*ENSMUSG0000004036711
Shoc2 / O88520 / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA. / Q9UQ13* / SHOC2, leucine rich repeat scaffold protein*ENSMUSG0000002497610
Lrrc40 / leucine-rich repeat-containing protein 40 isoform b / Q9H9A6* / leucine rich repeat containing 40*ENSMUSG000000630529
A6H6A4 / Lrriq4 / Leucine-rich repeat and IQ domain-containing protein 4 / A6NIV6* / leucine rich repeats and IQ motif containing 4*ENSMUSG000000277039
Lrrc10 / Q8K3W2 / Leucine-rich repeat-containing protein 10 / Q5BKY1* / leucine rich repeat containing 10*ENSMUSG000000601875
Lrrc10b / leucine rich repeat containing 10B / A6NIK2*ENSMUSG000000902915
Lrrc30 / leucine rich repeat containing 30 / A6NM36*ENSMUSG000000733754


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0008431 abnormal short-term spatial reference memory "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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