ENSMUSG00000021709


Mus musculus

Features
Gene ID: ENSMUSG00000021709
  
Biological name :Erbin
  
Synonyms : Erbin / Q80TH2
  
Possible biological names infered from orthology : erbb2 interacting protein / Q96RT1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 103818787
Gene end: 103920514
  
Corresponding Affymetrix probe sets: 10411853 (MoGene1.0st)   1428011_a_at (Mouse Genome 430 2.0 Array)   1439079_a_at (Mouse Genome 430 2.0 Array)   1439080_at (Mouse Genome 430 2.0 Array)   1439638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140536
Ensembl peptide - ENSMUSP00000088813
Ensembl peptide - ENSMUSP00000140931
Ensembl peptide - ENSMUSP00000127607
Ensembl peptide - ENSMUSP00000022222
Ensembl peptide - ENSMUSP00000057956
NCBI entrez gene - 59079     See in Manteia.
MGI - MGI:1890169
RefSeq - NM_001289473
RefSeq - NM_001289474
RefSeq - NM_001289475
RefSeq - NM_001005868
RefSeq Peptide - NP_001005868
RefSeq Peptide - NP_001276403
RefSeq Peptide - NP_001276404
RefSeq Peptide - NP_001276402
swissprot - Q80TH2
swissprot - B2RUK2
swissprot - B2RUJ2
swissprot - B7ZNX6
Ensembl - ENSMUSG00000021709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbinENSDARG00000044281Danio rerio
 ERBINENSGALG00000014773Gallus gallus
 ERBINENSG00000112851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc7 / leucine rich repeat containing 7 / Q96NW7*ENSMUSG0000002817641
Scrib / Q80U72 / scribbled planar cell polarity protein / Q14160*ENSMUSG0000002256823
Lrrc1 / Q80VQ1 / Leucine-rich repeat-containing protein 1 / Q9BTT6* / leucine rich repeat containing 1*ENSMUSG0000003235214
Mfhas1 / Q3V1N1 / Malignant fibrous histiocytoma-amplified sequence 1 homolog / Q9Y4C4* / malignant fibrous histiocytoma amplified sequence 1*ENSMUSG0000007005612
Shoc2 / O88520 / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA. / Q9UQ13* / SHOC2, leucine rich repeat scaffold protein*ENSMUSG0000002497610
Lrrd1 / Q8C0R9 / Leucine-rich repeat and death domain-containing protein 1 / A4D1F6* / leucine rich repeats and death domain containing 1*ENSMUSG0000004036710
A6H6A4 / Lrriq4 / Leucine-rich repeat and IQ domain-containing protein 4 / A6NIV6* / leucine rich repeats and IQ motif containing 4*ENSMUSG0000002770310
Lrrc40 / leucine-rich repeat-containing protein 40 isoform b / Q9H9A6* / leucine rich repeat containing 40*ENSMUSG000000630529
Lrrc10b / leucine rich repeat containing 10B / A6NIK2*ENSMUSG000000902915
Lrrc10 / Q8K3W2 / Leucine-rich repeat-containing protein 10 / Q5BKY1* / leucine rich repeat containing 10*ENSMUSG000000601875
Lrrc30 / leucine rich repeat containing 30 / A6NM36*ENSMUSG000000733754


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032927  Erbin
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032495 response to muramyl dipeptide ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030056 hemidesmosome ISO
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005176 ErbB-2 class receptor binding IEA
 molecular_functionGO:0005178 integrin binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: ErbinGt(BGA258)Byg/ErbinGt(BGA258)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex






 

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