ENSMUSG00000028017


Mus musculus

Features
Gene ID: ENSMUSG00000028017
  
Biological name :Egf
  
Synonyms : Egf / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01132
  
Possible biological names infered from orthology : epidermal growth factor / P01133
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 129677565
Gene end: 129755316
  
Corresponding Affymetrix probe sets: 10502105 (MoGene1.0st)   1418093_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143075
Ensembl peptide - ENSMUSP00000143108
Ensembl peptide - ENSMUSP00000029653
Ensembl peptide - ENSMUSP00000142497
NCBI entrez gene - 13645     See in Manteia.
MGI - MGI:95290
RefSeq - XM_011240011
RefSeq - NM_001310737
RefSeq - NM_001329594
RefSeq - NM_010113
RefSeq - XM_006500990
RefSeq - XM_011240010
RefSeq Peptide - NP_034243
RefSeq Peptide - NP_001316523
RefSeq Peptide - NP_001297666
swissprot - A0A0G2JDT8
swissprot - A0A0G2JF92
swissprot - A0A0G2JFB8
swissprot - P01132
Ensembl - ENSMUSG00000028017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egfENSDARG00000052739Danio rerio
 EGFENSGALG00000012155Gallus gallus
 EGFENSG00000138798Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nid2 / O88322 / Nidogen-2 / Q14112*ENSMUSG0000002180615
Nid1 / P10493 / Nidogen-1 / P14543*ENSMUSG0000000539714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR016317  Pro-epidermal growth factor
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IGI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IBA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IDA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051223 regulation of protein transport ISO
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IBA
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060749 mammary gland alveolus development IGI
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IDA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0090279 regulation of calcium ion import IEA
 biological_processGO:0090370 negative regulation of cholesterol efflux IDA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:2000008 regulation of protein localization to cell surface IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IBA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0005154 epidermal growth factor receptor binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002580 duodenal lesions "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001036 Epn2 / Q8CHU3 / Epsin-2 / O95208*  / reaction / complex
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / reaction / complex
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000026126 Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000037211 Spry1 / Q9QXV9 / sprouty RTK signaling antagonist 1 / O43609*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000035203 Epn1 / Q80VP1 / Epsin-1 / Q9Y6I3*  / reaction / complex
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction
 ENSMUSG00000052593 Adam17 / Q9Z0F8 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536* / ADAM metallopeptidase domain 17*  / reaction
 ENSMUSG00000054555 Adam12 / Q61824 / Disintegrin and metalloproteinase domain-containing protein 12 / O43184* / ADAM metallopeptidase domain 12*  / reaction
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex






 

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