ENSMUSG00000054693


Mus musculus

Features
Gene ID: ENSMUSG00000054693
  
Biological name :Adam10
  
Synonyms : Adam10 / Disintegrin and metalloproteinase domain-containing protein 10 / O35598
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 10 / O14672
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 70678997
Gene end: 70780229
  
Corresponding Affymetrix probe sets: 10586844 (MoGene1.0st)   1428103_at (Mouse Genome 430 2.0 Array)   1450104_at (Mouse Genome 430 2.0 Array)   1450105_at (Mouse Genome 430 2.0 Array)   1460083_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063839
Ensembl peptide - ENSMUSP00000117162
Ensembl peptide - ENSMUSP00000116867
NCBI entrez gene - 11487     See in Manteia.
MGI - MGI:109548
RefSeq - NM_007399
RefSeq - XM_011242657
RefSeq Peptide - NP_031425
swissprot - E9PYF2
swissprot - O35598
swissprot - D3Z1E6
Ensembl - ENSMUSG00000054693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam10aENSDARG00000053468Danio rerio
 adam10bENSDARG00000015502Danio rerio
 ADAM10ENSGALG00000004212Gallus gallus
 ADAM10ENSG00000137845Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam17 / Q9Z0F8 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536* / ADAM metallopeptidase domain 17*ENSMUSG0000005259327


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR027053  Disintegrin and metalloproteinase domain-containing protein 10
 IPR034025  ADAM10/ADAM17 catalytic domain
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0006913 nucleocytoplasmic transport NAS
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042117 monocyte activation IEA
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis IEA
 biological_processGO:0051089 constitutive protein ectodomain proteolysis IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IEA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0042169 SH2 domain binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0000844 abnormal pontine flexure "malformation or absence of the bend in the developing neural tube that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and medulla oblongata in the embryo" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0001725 abnormal umbilical cord "malformed connective stalk between the fetus and the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Adam10tm1.1Zhu/Adam10tm1.1Zhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam10tm1.1Zhu/Adam10tm1.1Zhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adam10tm1.1Zhu/Adam10tm1.1Zhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Adam10tm1Beni/Adam10tm1Beni,Adam17tm1.1Srj/Adam17tm1.1Srj,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Zhu/Adam10tm1.1Zhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adam10tm1.1Khr/Adam10tm1.1Khr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hand1tm1.1(EGFP/cre)Abfi/Hand1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

Allelic Composition: Adam10tm1.1Zhu/Adam10tm1.1Zhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adam10tm1Beni/Adam10tm1Beni,Adam17tm1.1Srj/Adam17tm1.1Srj,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0012254 absent intersomitic vessels "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0013577 forestomach hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the distinct rodent non-glandular region of the stomach which is demarcated from the glandular stomach by the limiting ridge (margo plicatus)" [MGI:Anna]
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Allelic Composition: Tbx5tm1.2Jse/Tbx5tm1.2Jse
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003070 Efna2 / P52801 / Ephrin-A2 / O43921*  / complex
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / complex
 ENSMUSG00000027276 Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000027314 Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*  / reaction
 ENSMUSG00000014773 Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*  / reaction
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / reaction
 ENSMUSG00000002799 Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*  / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / reaction






 

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