ENSGALG00000004212


Gallus gallus

Features
Gene ID: ENSGALG00000004212
  
Biological name :ADAM10
  
Synonyms : ADAM10 / ADAM metallopeptidase domain 10
  
Possible biological names infered from orthology : Disintegrin and metalloproteinase domain-containing protein 10 / O14672 / O35598
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 6872425
Gene end: 6915022
  
Corresponding Affymetrix probe sets: Gga.1343.1.S1_at (Chicken Array)   Gga.1343.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006687
Ensembl peptide - ENSGALP00000064304
Ensembl peptide - ENSGALP00000062351
NCBI entrez gene - 374113     See in Manteia.
RefSeq - NM_204261
RefSeq Peptide - NP_989592
swissprot - A0A1L1RZJ8
swissprot - A0A1L1RU47
swissprot - Q5F3N4
Ensembl - ENSGALG00000004212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam10aENSDARG00000053468Danio rerio
 adam10bENSDARG00000015502Danio rerio
 ADAM10ENSG00000137845Homo sapiens
 Adam10ENSMUSG00000054693Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM17 / disintegrin and metalloproteinase domain-containing protein 17 precursor / P78536* / Q9Z0F8* / ADAM metallopeptidase domain 17* / Disintegrin and metalloproteinase domain-containi...ENSGALG0000001642726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR027053  Disintegrin and metalloproteinase domain-containing protein 10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042117 monocyte activation IEA
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis IEA
 biological_processGO:0051089 constitutive protein ectodomain proteolysis IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IEA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000608 CDH1 / cadherin 1 / P12830*  / reaction






 

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