ENSGALG00000016427


Gallus gallus

Features
Gene ID: ENSGALG00000016427
  
Biological name :ADAM17
  
Synonyms : ADAM17 / disintegrin and metalloproteinase domain-containing protein 17 precursor
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 17 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536 / Q9Z0F8
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 96629036
Gene end: 96661484
  
Corresponding Affymetrix probe sets: Gga.7793.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000030970
NCBI entrez gene - 421931     See in Manteia.
RefSeq - NM_001008682
RefSeq Peptide - NP_001008682
swissprot - Q5QHR9
Ensembl - ENSGALG00000016427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam17aENSDARG00000043213Danio rerio
 adam17bENSDARG00000093093Danio rerio
 ADAM17ENSG00000151694Homo sapiens
 Adam17ENSMUSG00000052593Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM10 / ADAM metallopeptidase domain 10 / O14672* / O35598* / Disintegrin and metalloproteinase domain-containing protein 10 *ENSGALG0000000421224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR032029  ADAM17, membrane-proximal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis IEA
 biological_processGO:0071403 cellular response to high density lipoprotein particle stimulus IEA
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulated proteolysis of p75NTR


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / reaction






 

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