ENSMUSG00000052593


Mus musculus

Features
Gene ID: ENSMUSG00000052593
  
Biological name :Adam17
  
Synonyms : Adam17 / Disintegrin and metalloproteinase domain-containing protein 17 / Q9Z0F8
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 17 / P78536
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.3
Gene start: 21323509
Gene end: 21373632
  
Corresponding Affymetrix probe sets: 10399605 (MoGene1.0st)   1421857_at (Mouse Genome 430 2.0 Array)   1421858_at (Mouse Genome 430 2.0 Array)   1421859_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136407
Ensembl peptide - ENSMUSP00000136677
Ensembl peptide - ENSMUSP00000099087
Ensembl peptide - ENSMUSP00000067953
Ensembl peptide - ENSMUSP00000136255
NCBI entrez gene - 11491     See in Manteia.
MGI - MGI:1096335
RefSeq - NM_009615
RefSeq - NM_001277266
RefSeq - NM_001291871
RefSeq Peptide - NP_001264195
RefSeq Peptide - NP_033745
RefSeq Peptide - NP_001278800
swissprot - Q9Z0F8
swissprot - E9PXU2
swissprot - J3QMF2
swissprot - J3QNB3
Ensembl - ENSMUSG00000052593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam17aENSDARG00000043213Danio rerio
 adam17bENSDARG00000093093Danio rerio
 ADAM17ENSGALG00000016427Gallus gallus
 ADAM17ENSG00000151694Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*ENSMUSG0000005469324


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR032029  ADAM17, membrane-proximal domain
 IPR034025  ADAM10/ADAM17 catalytic domain
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002467 germinal center formation IMP
 biological_processGO:0002532 production of molecular mediator involved in inflammatory response IDA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006509 membrane protein ectodomain proteolysis ISO
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway ISO
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing ISO
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010820 positive regulation of T cell chemotaxis ISO
 biological_processGO:0010977 negative regulation of neuron projection development IGI
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0033025 regulation of mast cell apoptotic process IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033627 cell adhesion mediated by integrin ISO
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway ISO
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity ISO
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048679 regulation of axon regeneration IGI
 biological_processGO:0048870 cell motility IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium ISO
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis IDA
 biological_processGO:0051272 positive regulation of cellular component movement IMP
 biological_processGO:0071403 cellular response to high density lipoprotein particle stimulus ISO
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2001222 regulation of neuron migration IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0032587 ruffle membrane ISO
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005138 interleukin-6 receptor binding ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulated proteolysis of p75NTR
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Wesh/Adam17tm1.2Wesh
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0000384 distorted hair follicle pattern "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]
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Allelic Composition: Adam17tm1Srj/Adam17tm1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Npr2cn-3J/Npr2cn-3J
Genetic Background: MRL/MpJ-Npr2cn-3J/GrsrJ

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Npr2cn-3J/Npr2cn-3J
Genetic Background: MRL/MpJ-Npr2cn-3J/GrsrJ

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Npr2cn-3J/Npr2cn-3J
Genetic Background: MRL/MpJ-Npr2cn-3J/GrsrJ

Allelic Composition: Adam17tm1.2Wesh/Adam17tm1.2Wesh
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * FVB/N

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Il1btm1Lvp/Il1btm1Lvp
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

Allelic Composition: Adam17tm1Imx/Adam17woe
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.2Wesh/Adam17tm1.2Wesh
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001316 corneal scarring "appearance of fibrous tissue on the cornea after healing in response to injury " [J:30249]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Npr2cn-3J/Npr2cn-3J
Genetic Background: MRL/MpJ-Npr2cn-3J/GrsrJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrtm1Ofc/Atrtm1Ofc,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhbdf2tm1Mak/Rhbdf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adam17tm1Srj/Adam17tm1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17tm1Imx/Adam17woe
Genetic Background: involves: 129 * C57BL/6

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: C57BL/6J

Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain
Genetic Background: C57BL/6-Adam17tm1.2Rain

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain
Genetic Background: C57BL/6-Adam17tm1.2Rain

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain
Genetic Background: C57BL/6-Adam17tm1.2Rain

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0004283 absent corneal endothelium "absence of the single layer of large flattened cells that cover the surface of the cornea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0004285 absent Descemet membrane "absence of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [J:4605, J:73681, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0004545 enlarged esophagus "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0005204 abnormal canal of Schlemm morphology "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0006236 absent meibomian glands "missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Wesh/Adam17tm1.2Wesh
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * FVB/N

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

Allelic Composition: Adam17tm1Rain/Adam17tm1Rain
Genetic Background: involves: C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0010595 abnormal aortic valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0010605 thick pulmonary valve cusps "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010626 thick tricuspid valve cusps 
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Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Adam17tm1.1Bbl/Adam17tm1.1Bbl
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adam17tm1.2Wesh/Adam17tm1.2Wesh
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain
Genetic Background: C57BL/6-Adam17tm1.2Rain

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adam10tm1Beni/Adam10tm1Beni,Adam17tm1.1Srj/Adam17tm1.1Srj,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Adam17tm1Imx/Adam17tm1Imx
Genetic Background: involves: 129 * DBA/1J

Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
Show

Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0011929 abnormal aortic valve flow "abnormality impeding normal blood flow or allowing blood to backflow through this valve into the left ventricle" [MPD:Molly]
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Allelic Composition: Adam17tm1.1Rain/Adam17tm1.2Rain,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0013744 abnormal conjunctival sac morphology "any structural anomaly of the space bound by the conjunctival membrane between the palpebral and bulbar conjunctiva, into which the lacrimal fluid is secreted; it is a closed space when eye is closed; when eye is open, the sac is open anteriorly through the palpebral fissure (between the eyelids)" [http://www.medilexicon.com/medicaldictionary.php?t=79277, MGI:Anna]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0013745 abnormal eyelid margin morphology "any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium" [http://one.aao.org/bcscsnippetdetail.aspx?id=2b7328d7-5eb2-4df3-812a-031ff1c1f904, http://www.medilexicon.com/medicaldictionary.php?s=palpebral+margins, MGI:Anna]
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Allelic Composition: Adam17woe/Adam17woe
Genetic Background: C57BL/6-Adam17woe

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

Allelic Composition: Adam17tm1Rain/Adam17tm1Rain
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / reaction






 

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