ENSMUSG00000024401


Mus musculus

Features
Gene ID: ENSMUSG00000024401
  
Biological name :Tnf
  
Synonyms : P06804 / Tnf / tumor necrosis factor
  
Possible biological names infered from orthology : P01375
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35199381
Gene end: 35202007
  
Corresponding Affymetrix probe sets: 10450501 (MoGene1.0st)   1419607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025263
Ensembl peptide - ENSMUSP00000126122
NCBI entrez gene - 21926     See in Manteia.
MGI - MGI:104798
RefSeq - NM_001278601
RefSeq - NM_013693
RefSeq Peptide - NP_001265530
RefSeq Peptide - NP_038721
swissprot - Q3U593
swissprot - P06804
swissprot - A0A0R4J210
Ensembl - ENSMUSG00000024401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaENSDARG00000009511Danio rerio
 tnfbENSDARG00000013598Danio rerio
 TNFENSG00000232810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*ENSMUSG0000002440229
Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15 / O95150* / TNF superfamily member 15*ENSMUSG0000005039526
Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...ENSMUSG0000000081724
Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...ENSMUSG0000000582423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002959  Tumour necrosis factor alpha
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0002439 chronic inflammatory response to antigenic stimulus IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus IGI
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IGI
 biological_processGO:0006006 glucose metabolic process IDA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007254 JNK cascade IGI
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IDA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0030316 osteoclast differentiation IGI
 biological_processGO:0030730 sequestering of triglyceride IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031622 positive regulation of fever generation IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IGI
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032800 receptor biosynthetic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IDA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043242 negative regulation of protein complex disassembly IEA
 biological_processGO:0043243 positive regulation of protein complex disassembly IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IGI
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045123 cellular extravasation IDA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IDA
 biological_processGO:0045670 regulation of osteoclast differentiation IDA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045994 positive regulation of translational initiation by iron IDA
 biological_processGO:0046325 negative regulation of glucose import IDA
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050708 regulation of protein secretion IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IGI
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IDA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051222 positive regulation of protein transport IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051798 positive regulation of hair follicle development IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060557 positive regulation of vitamin D biosynthetic process IEA
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity IEA
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IDA
 biological_processGO:0060693 regulation of branching involved in salivary gland morphogenesis IMP
 biological_processGO:0061048 negative regulation of branching involved in lung morphogenesis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:0072577 endothelial cell apoptotic process IDA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901671 positive regulation of superoxide dismutase activity IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IEA
 biological_processGO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 biological_processGO:2000334 positive regulation of blood microparticle formation IEA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule TAS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0055037 recycling endosome IDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Tnftm1.2Sned/Tnftm1.2Sned
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6 * SPRET/Ei

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Foxc1hith/Foxc1hith,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Foxc1hith/Foxc1hith,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Nfkbiztm1.1Muta/Nfkbiztm1.1Muta,Tg(KRT5-cre)1Tak/?
Genetic Background: involves: C3H * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ppp1r1btm4Pggd/Ppp1r1btm4Pggd
Genetic Background: Not Specified

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxc1hith/Foxc1hith,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1hith/Foxc1hith,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Thtm1Tna/Th+
Genetic Background: B6.129-Thtm1Tna

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mybpc3tm1Rmos/Mybpc3tm1Rmos
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt8tm1Rgo/Krt8tm1Rgo
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6-Lta/Tnftm1Jods

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfaptm2Mes/Gfap+,Tg(GFAP)10Mes/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Itgb7tm1Cgn/Itgb7tm1Cgn,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxc1hith/Foxc1hith,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6-Lta/Tnftm1Jods

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0002363 abnormal spleen marginal sinus morphology "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six5tm1Tap/Six5+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: involves: C57BL/6

Allelic Composition: TnfR8H/TnfR8H
Genetic Background: I/St

Allelic Composition: TnfM1Btlr/TnfM1Btlr
Genetic Background: C57BL/6J-TnfM1Btlr

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Lta/Tnftm1Fda/Lta/Tnftm1Fda
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lta/Tnftm1Fda/Tnf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppp1r1btm4Pggd/Ppp1r1btm4Pggd
Genetic Background: Not Specified

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Tnftm1.2Sned/Tnftm1.2Sned
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6 * SPRET/Ei

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Tnftm2Gkl/Tnf+,Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl,Tg(Col6a1-cre)1Gkl/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Itgb7tm1Cgn/Itgb7tm1Cgn,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6 * SPRET/Ei

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: B2mtm1Jae/B2mtm1Jae,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Cd4tm1Mak/Cd4tm1Mak,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Allelic Composition: Tcrdtm1Mom/Tcrdtm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Mapk9tm1Flv/Mapk9tm1Flv,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Tnftm2Gkl/Tnf+,Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl,Tg(Col6a1-cre)1Gkl/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Myo5argsc235/Myo5argsc235
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: C.129S-Tnftm1Gkl

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: C57BL/6-Tnftm1Jods

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: C57BL/6-Ltatm1Jods

Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6-Lta/Tnftm1Jods

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1.2Sned/Tnftm1.2Sned
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1Ljo/Tnf+
Genetic Background: involves: 129S1/Sv

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005667 abnormal circulating leptin level "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Mapk9tm1Flv/Mapk9tm1Flv,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapkapk2tm1Mgl/Mapkapk2tm1Mgl,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: B6.129S1-Tnftm1Ljo

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0006167 eyelid edema "an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic Background: C57BL/6J-Lta/Tnftm1Jods

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008197 abnormal follicular dendritic cell physiology "abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

 MP:0008200 decreased follicular dendritic cell number "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: TnfM1Btlr/TnfM1Btlr
Genetic Background: C57BL/6J-TnfM1Btlr

Allelic Composition: TnfM1Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM1Btlr

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: either: B6.129-Tnftm1Ljo or (involves: 129/Sv * C57BL/6)

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1op/Csf1op,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: B6.129S1-Tnftm1Ljo

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008464 absent peripheral lymph nodes "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: C57BL/6-Ltatm1Jods

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008473 abnormal spleen follicular dendritic cell network "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tnftm2Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnftm2Gkl,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tnftm1Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnftm2Gkl,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Lta/Tnftm1Fda/Lta/Tnftm1Fda
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lta/Tnftm1Fda/Tnf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: TnfM2Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM2Btlr

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: C57BL/6-Tnftm1Jods

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tnftm1Jods/Tnftm1Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: C57BL/6-Tnftm2Jods

Allelic Composition: Tnftm1Sek/Tnftm1Sek
Genetic Background: B6.Cg-Tnftm1Sek

Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Lta/Tnftm1Fda/Lta/Tnftm1Fda
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lta/Tnftm1Fda/Tnf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1Gkl/Tnftm2Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Tnftm2Jods/Tnftm2Jods
Genetic Background: involves: C57BL/6

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008978 abnormal vagina weight "anomaly in the weight of the female reproductive canal located between the uterus and the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0009405 increased skeletal muscle fiber number "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

Allelic Composition: Cd44tm1Hbg/Cd44+,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: TnfR8H/TnfR8H
Genetic Background: I/St

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129/Sv

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: B6.129-Lta/Tnftm1Eug

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010222 abnormal T-helper 17 cell physiology "any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: TnfM2Btlr/Tnf+
Genetic Background: C57BL/6J-TnfM2Btlr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Kmt2etm1Apa/Kmt2etm1Apa
Genetic Background: 129S6/SvEvTac-Kmt2etm1Apa

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Krt8tm1Rgo/Krt8tm1Rgo,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Tnftm1Gkl/Tnftm1Gkl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum

 MP:0014079 decreased small intestinal villus number "fewer than normal numbers of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
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Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0030466 alveolar process atrophy "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0030582 abnormal hair follicle placode formation "any anomaly in the developmental process in which a hair placode forms; in mouse, hair placode formation is initiated at ~E13.5 in response to the first dermal signal originating from dermal fibroblasts; the resulting primary hair placode cells signal to the underlying dermis, triggering formation of dermal condensates that will coordinate further differentiation of hair-forming cells; hair placode formation progresses through 3 successive waves (1) primary hair placodes form at E14.5 and produce guard hair, (2) secondary hair placodes form at E16-17 and produce awl hair, and (3) the third wave of hair follicle induction produces tertiary placodes and generate zig-zag hair" [GO:0060789, https://discovery.lifemapsc.com/in-vivo-development/hair/hair-follicle/primary-hair-placode-cells]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000019822 Smpd2 / O70572 / sphingomyelin phosphodiesterase 2, neutral / O60906* / sphingomyelin phosphodiesterase 2*  / reaction / complex
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSMUSG00000028245 Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / complex / reaction
 ENSMUSG00000020372 Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000028599 P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000037316 Bag4 / Q8CI61 / BAG family molecular chaperone regulator 4 / O95429* / BCL2 associated athanogene 4*  / reaction
 ENSMUSG00000031906 Smpd3 / Q9JJY3 / sphingomyelin phosphodiesterase 3, neutral / Q9NY59* / sphingomyelin phosphodiesterase 3*  / reaction / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex
 ENSMUSG00000052593 Adam17 / Q9Z0F8 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536* / ADAM metallopeptidase domain 17*  / reaction






 

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