ENSMUSG00000019822


Mus musculus

Features
Gene ID: ENSMUSG00000019822
  
Biological name :Smpd2
  
Synonyms : O70572 / Smpd2 / sphingomyelin phosphodiesterase 2, neutral
  
Possible biological names infered from orthology : O60906 / sphingomyelin phosphodiesterase 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B2
Gene start: 41485642
Gene end: 41490369
  
Corresponding Affymetrix probe sets: 10368806 (MoGene1.0st)   1416999_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019965
Ensembl peptide - ENSMUSP00000115461
NCBI entrez gene - 20598     See in Manteia.
MGI - MGI:1278330
RefSeq - XM_017313862
RefSeq - NM_009213
RefSeq - XM_006512633
RefSeq Peptide - NP_033239
swissprot - O70572
swissprot - D6RGM4
Ensembl - ENSMUSG00000019822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpd2aENSDARG00000040523Danio rerio
 smpd2bENSDARG00000052701Danio rerio
 SMPD2ENSGALG00000033245Gallus gallus
 SMPD2ENSG00000135587Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0046513 ceramide biosynthetic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020372 Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / reaction / complex
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSMUSG00000028245 Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / reaction / complex






 

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contact: otassy@igbmc.fr