Manteia - Molecule gene

ENSMUSG00000030341

Mus musculus

Features

Gene ID:	ENSMUSG00000030341

Biological name :	Tnfrsf1a

Synonyms :	P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a

Possible biological names infered from orthology :	P19438 / TNF receptor superfamily member 1A

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	F3
Gene start:	125349362
Gene end:	125362484

Corresponding Affymetrix probe sets:	10541895 (MoGene1.0st) 1417291_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000121968 Ensembl peptide - ENSMUSP00000115991 Ensembl peptide - ENSMUSP00000032491 Ensembl peptide - ENSMUSP00000117470 NCBI entrez gene - 21937 See in Manteia. MGI - MGI:1314884 RefSeq - NM_011609 RefSeq Peptide - NP_035739 swissprot - Q3U479 swissprot - D3YXL4 swissprot - F6R6K0 swissprot - F7A4X5 swissprot - P25118 Ensembl - ENSMUSG00000030341

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tnfrsf1a	ENSDARG00000018569	Danio rerio
TNFRSF1A	ENSGALG00000039461	Gallus gallus
P19438	ENSG00000067182	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tnfrsf25 / tumor necrosis factor receptor superfamily, member 25 / Q93038* / TNF receptor superfamily member 25*	ENSMUSG00000024793	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000488	Death domain
IPR001368	TNFR/NGFR cysteine-rich region
IPR011029	Death-like domain superfamily
IPR020419	Tumour necrosis factor receptor 1A
IPR033993	Tumor necrosis factor receptor 1A, N-terminal
IPR033994	Tumor necrosis factor receptor 1A, death domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006693	prostaglandin metabolic process	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006952	defense response	IMP
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IMP
biological_process	GO:0007275	multicellular organism development	IBA
biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP
biological_process	GO:0019221	cytokine-mediated signaling pathway	IMP
biological_process	GO:0032496	response to lipopolysaccharide	IBA
biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IEA
biological_process	GO:0042742	defense response to bacterium	IMP
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0050728	negative regulation of inflammatory response	IEA
biological_process	GO:0050729	positive regulation of inflammatory response	IMP
biological_process	GO:0071260	cellular response to mechanical stimulus	IEA
biological_process	GO:0072659	protein localization to plasma membrane	IEA
biological_process	GO:1903140	regulation of establishment of endothelial barrier	IEA
cellular_component	GO:0000139	Golgi membrane	ISO
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005739	mitochondrion	IBA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0043235	receptor complex	IEA
cellular_component	GO:0045121	membrane raft	IEA
molecular_function	GO:0005031	tumor necrosis factor-activated receptor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0043120	tumor necrosis factor binding	IBA

Pathways (from Reactome)

Pathway description

TNFR1-induced proapoptotic signaling

Regulation of TNFR1 signaling

TNFR1-induced NFkappaB signaling pathway

TNFR1-mediated ceramide production

TNFs bind their physiological receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn Genetic Background: involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Tab2^tm2.1Aki/Tab2^tm2.1Aki,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mog^tm1Dpd/Mog^tm1Dpd,Rag2^tm1Cgn/Rag2^tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Ikbkb^tm1Ver/Ikbkb^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn,Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl,Tg(KRT14-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Chuk^tm1Yhu/Chuk^tm1Yhu,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Chuk^tm1Yhu/Chuk^tm1Yhu,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn,Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl,Tg(KRT14-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Tg(KRT5-Nfkbia)3Rto/0,Tg(Krt5-Tnfr1)#Rsab/0,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background:* involves: 129S2/SvPas * C57BL/6 * CBA
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tcirg1^tm1Utku/Tcirg1^tm1Utku Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Rela^tm1.1Gho/Rela^tm1.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
MP:0001313	increased incidence of corneal inflammation	"greater than average and persistent occurrence of corneal irritation" [J:4606]	Show Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0001501	abnormal sleep pattern	"deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: B6.129P2-Tnfrsf1a^tm1Blt
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001656	focal hepatic necrosis	"a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnf^tm1Ljo/Tnf⁺ Genetic Background: involves: 129S1/Sv Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0001845	abnormal inflammatory response	"aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6J Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6J
MP:0001853	heart inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei Allelic Composition: Tnfrsf1a^tm1Gkl/Tnfrsf1a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal,Tnfrsf1a^tm1Gkl/Tnfrsf1a^tm1Gkl Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fas^lpr/Fas^lpr,Tnfrsf1a^tm1Gkl/Tnfrsf1a^tm1Gkl Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Gkl/Tnfrsf1a^tm1Gkl,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0001862	interstitial pneumonia	"disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rela^tm1.1Gho/Rela^tm1.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
MP:0002051	skin papilloma	"a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002052	decreased tumor incidence	"less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bax^tm1Dlo/Bax^tm1Dlo Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Chuk^tm1Yhu/Chuk^tm1Yhu,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tg(KRT5-cre)5132Jlj/0 Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcirg1^tm1Utku/Tcirg1^tm1Utku Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Rela^tm1.1Gho/Rela^tm1.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 Allelic Composition: Rela^tm1.2Gho/Rela^tm1.2Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ikbkg^tm1.1Dwat/Ikbkg^tm1.1Dwat,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il13^tm1Anjm/Il13^tm1Anjm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002314	abnormal respiratory mechanics	"anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002334	abnormal airway responsiveness	"anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002343	abnormal lymph node cortex	"anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002344	abnormal lymph node B cell domain	"anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002345	abnormal lymph node primary follicle	"anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002346	abnormal lymph node secondary follicle	"anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt Genetic Background: involves: 129S7/SvEvBrd * DBA/1OlaHsd Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0002359	abnormal spleen germinal center morphology	"anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002389	abnormal Peyer s patch follicle morphology	"anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002450	abnormal lymph organ development	"anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mc1r^e/Mc1r^e,Mlph^ln/Mlph^ln Genetic Background: Not Specified
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ehmt1^tm1Yshk/Ehmt1⁺ Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0002500	granulomatous inflammation	"chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tbk1^tm1Aki/Tbk1^tm1Aki Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0002658	abnormal liver regeneration	"deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002796	impaired skin barrier function	"impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002886	abnormal glutamate receptor currents	"change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0002942	decreased circulating alanine transaminase level	"decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0002993	arthritis	"joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei Allelic Composition: Tnf^tm2Gkl/Tnf⁺,Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl,Tg(Col6a1-cre)1Gkl/? Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0002999	abnormal bone healing	"defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei
MP:0003037	increased infarction size	"increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Ikbkb^tm1Ver/Ikbkb^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003306	small intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tnf^tm2Gkl/Tnf⁺,Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl,Tg(Col6a1-cre)1Gkl/? Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Xbp1^tm2Glm/Xbp1^tm2Glm,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003329	amyloid beta deposits		Show Allelic Composition: Pomc^tm1Low/Pomc^tm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx Allelic Composition: Tg(Gfap-TNF)K21Gkl/0,Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm3.1Gkl/Tnfrsf1a⁺,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Tnfrsf1a^tm3.1Gkl/Tnfrsf1a^tm3.1Gkl,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a⁺ Genetic Background: involves: 129S2/SvPas
MP:0003690	abnormal glial cell physiology	"anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004254	cerebral amyloid angiopathy	"a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator]	Show Allelic Composition: Pomc^tm1Low/Pomc^tm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
MP:0004574	broad limb buds	"increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Ikbkb^tm1Ver/Ikbkb^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fas^tm1Cgn/Fas^tm1Cgn,Mog^tm1(cre)Gkl/Mog⁺,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Fas^tm1Cgn/Fas^tm1Cgn,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0004801	increased susceptibility to systemic lupus erythematosus	"greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0004803	increased susceptibility to autoimmune diabetes	"greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk,Tg(INS-Il10)#Sar/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD
MP:0004804	decreased susceptibility to autoimmune diabetes	"reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk,Tg(INS-Il10)#Sar/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004822	decreased susceptibility to experimental autoimmune uveoretinitis	"reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004938	dilated vasculature	"stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn,Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl,Tg(KRT14-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 Allelic Composition: Tg(KRT5-Nfkbia)3Rto/0,Tg(Krt5-Tnfr1)#Rsab/0,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background:* involves: 129S2/SvPas * C57BL/6 * CBA
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004994	abnormal brain wave pattern	"any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6J Allelic Composition: Tnfaip3^tm1Ama/Tnfaip3^tm1Ama,Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6J
MP:0005190	osteomyelitis	"bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mc1r^e/Mc1r^e,Mlph^ln/Mlph^ln Genetic Background: Not Specified
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^W-82J/Kit⁺ Genetic Background: involves: C3HeB/FeLe
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0005399	increased susceptibility to fungal infection	"greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0005543	corneal thinning	"decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk,Tg(INS-Il10)#Sar/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD
MP:0005596	increased susceptibility to type I hypersensitvity reaction	"greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006000	abnormal corneal epithelium	"malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0006050	pulmonary fibrosis	"formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006060	increased cerebral infarction size	"increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008133	decreased Peyer s patch number	"reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008135	small Peyer s patches	"reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008196	abnormal follicular dendritic cell morphology	"any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008201	absent follicular dendritic cells	"absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008235	increased susceptibility to neuronal excitotoxicity	"greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008474	absent spleen germinal center	"absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0008523	absent lymph node germinal center	"absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt,Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mir451a^tm1.2Doca/Mir451a^tm1.2Doca Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ
MP:0008539	decreased susceptibility to induced colitis	"decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mir451a^tm1.2Doca/Mir451a^tm1.2Doca Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Tnf^tm2Gkl/Tnf^tm2Gkl,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Tnf^tm2Gkl/Tnf^tm2Gkl,Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0008597	decreased circulating interleukin-6 level	"reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a⁺ Genetic Background: involves: 129S2/SvPas
MP:0008642	decreased circulating interleukin-1 beta level	"reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008719	impaired neutrophil recruitment	"reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008721	abnormal chemokine level	"deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008722	abnormal chemokine secretion	"anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008734	decreased susceptibility to endotoxin shock	"less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J
MP:0008735	increased susceptibility to endotoxin shock	"more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tnf^tm2Gkl/Tnf⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pomc^tm1Low/Pomc^tm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
MP:0008943	increased sensitivity to induced cell death	"decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tert^tm1Yjc/Tert^tm1Yjc Genetic Background: involves: C57BL/6 * SPRET/Ei Allelic Composition: Tnfrsf1a^tm1Gkl/Tnfrsf1a⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm2Gkl/Tnfrsf1a⁺,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * SJL
MP:0009764	decreased sensitivity to induced morbidity/mortality	"increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx/J Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm3.1Gkl/Tnfrsf1a⁺,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Tnfrsf1a^tm3.1Gkl/Tnfrsf1a^tm3.1Gkl,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Tnfrsf1a^{tm4.1(TNFRSF1A)Gkl}/Tnfrsf1a⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a⁺ Genetic Background: involves: 129S2/SvPas
MP:0009767	decreased sensitivity to xenobiotic induced morbidity/mortality	"increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tnf^tm2Gkl/Tnf⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
MP:0009788	increased susceptibility to bacterial infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd
MP:0009967	abnormal neuron proliferation	"any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0010042	abnormal oval cell physiology	"any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010155	abnormal intestine physiology	"any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^tm2Gkl/Tnfrsf1a⁺,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * SJL
MP:0010537	tumor regression	"a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf1a^{tm4.1(TNFRSF1A)Gkl}/Tnfrsf1a⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011020	abnormal circadian temperature homeostasis	"any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]	Show Allelic Composition: Lhx1^tm2.1Bhr/Lhx1^tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0011049	impaired adaptive thermogenesis	"inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]	Show Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺ Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rela^tm1Bal/Rela^tm1Bal,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Birc2^tm1.1Rbr/Birc2^tm1.1Rbr,Birc3^tm1.1Rbr/Birc3^tm1.1Rbr,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: BALB/cJ * C57BL/6 * SJL
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Tg(KRT5-Nfkbia)3Rto/0,Tg(Krt5-Tnfr1)#Rsab/0,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background:* involves: 129S2/SvPas * C57BL/6 * CBA
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 Allelic Composition: Tab2^tm2.1Aki/Tab2^tm2.1Aki,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver,Ikbkb^tm1Ver/Ikbkb^tm1Ver,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Rela^tm1.1Gho/Rela^tm1.1Gho,Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0011452	decreased susceptibility to dopaminergic neuron neurotoxicity	"less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011971	increased circulating lactate dehydrogenase level	"elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]	Show Allelic Composition: Ikbkg^tm1.1Dwat/Y,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
MP:0011982	decreased microglial cell number	"reduced number of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system" [PMID:22046273]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: C57BL/6-Tnfrsf1a^tm1Imx
MP:0013239	impaired skeletal muscle regeneration	"reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013251	dental pulp necrosis	"morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx,Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Cyld^tm1Scs/Cyld^tm1Scs,Ripk3^tm2Vmd/Ripk3^tm2Vmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MP:0020154	impaired humoral immune response	"impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]	Show Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Genetic Background: involves: C57BL/6 Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: involves: 129P2/OlaHsd
MP:0020449	decreased microglial cell activation	"decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]	Show Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx,Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0030012	impaired central nervous system regeneration	"reduced or delayed ability to regenerate healthy central nervous system tissue following injury or disease" [MGI:anna]	Show Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Genetic Background: B6.129P2-Tnfrsf1a^tm1Blt

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024401	Tnf / P06804 / tumor necrosis factor / P01375*	/ complex / reaction
ENSMUSG00000031887	Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*	/ reaction / complex
ENSMUSG00000024402	Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*	/ complex / reaction
ENSMUSG00000026942	Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*	/ complex / reaction
ENSMUSG00000020372	Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*	/ complex / reaction
ENSMUSG00000028245	Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*	/ reaction / complex
ENSMUSG00000021408	Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*	/ reaction / complex
ENSMUSG00000019822	Smpd2 / O70572 / sphingomyelin phosphodiesterase 2, neutral / O60906* / sphingomyelin phosphodiesterase 2*	/ complex / reaction
ENSMUSG00000031906	Smpd3 / Q9JJY3 / sphingomyelin phosphodiesterase 3, neutral / Q9NY59* / sphingomyelin phosphodiesterase 3*	/ complex / reaction
ENSMUSG00000030341	P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*	/ complex
ENSMUSG00000037316	Bag4 / Q8CI61 / BAG family molecular chaperone regulator 4 / O95429* / BCL2 associated athanogene 4*	/ complex
ENSMUSG00000057367	Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr