ENSMUSG00000031906


Mus musculus

Features
Gene ID: ENSMUSG00000031906
  
Biological name :Smpd3
  
Synonyms : Q9JJY3 / Smpd3 / sphingomyelin phosphodiesterase 3, neutral
  
Possible biological names infered from orthology : Q9NY59 / sphingomyelin phosphodiesterase 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 106252548
Gene end: 106337988
  
Corresponding Affymetrix probe sets: 10581479 (MoGene1.0st)   1422779_at (Mouse Genome 430 2.0 Array)   1438665_at (Mouse Genome 430 2.0 Array)   1450748_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069255
Ensembl peptide - ENSMUSP00000148282
NCBI entrez gene - 58994     See in Manteia.
MGI - MGI:1927578
RefSeq - XM_011248463
RefSeq - NM_021491
RefSeq - XM_006531241
RefSeq - XM_011248462
RefSeq Peptide - NP_067466
swissprot - Q9JJY3
Ensembl - ENSMUSG00000031906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpd3ENSDARG00000098226Danio rerio
 SMPD3ENSGALG00000034950Gallus gallus
 SMPD3ENSG00000103056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smpd5 / sphingomyelin phosphodiesterase 5ENSMUSG0000007172428


Protein motifs (from Interpro)
Interpro ID Name
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006684 sphingomyelin metabolic process IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030072 peptide hormone secretion IMP
 cellular_componentGO:0000137 Golgi cis cisterna IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003582 abnormal ovary development "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004189 abnormal alveolar process "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004373 bowed humerus "increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004506 abnormal pubic bone morphology "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004675 rib fractures "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005473 decreased triiodothyronine level "less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006322 abnormal perichondrium morphology "any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008338 decreased thyrotroph cell number "reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008341 decreased corticotroph cell number "reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

 MP:0010971 abnormal periosteum morphology "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: involves: C3H/HeN * C57BL/6N

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: B6N.Cg-Smpd3fro

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0013340 abnormal pituicyte morphology "any structural anomaly of the distinctive fusiform cells present in the pars nervosa of the posterior pituitary gland which resemble astrocytes/glial cells of the CNS and assist in the storage and release of neurohypophysial hormones" [MGI:Anna]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014162 decreased circulating cortisol level "less than the normal blood concentration of the principal glucocorticoid produced by the zona fasciculata of the adrenal cortex within the adrenal gland and released in response to stress and a low level of blood glucose" [https://en.wikipedia.org/wiki/Cortisol]
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Allelic Composition: Sh2d1atm1Lyin/Sh2d1atm1Lyin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030542 abnormal dentin development "any anomaly in the process whose specific outcome is the formation of dentin, the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root; dentinogenesis begins prior to enamel formation and is initiated by the odontoblasts of the dental pulp; dentin is derived from the dental papilla of the tooth germ; after apposition of predentin and maturation into dentin, the cell bodies of the odontoblasts remain in the pulp inside the tooth, along its outer wall; unlike enamel, dentin continues to form throughout life and can be initiated in response to stimuli, such as tooth decay or attrition" [GO:0097187, https://en.wikipedia.org/wiki/Dentin]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020372 Rack1 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed / P63244* / receptor for activated C kinase 1*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / reaction / complex
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSMUSG00000028245 Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / reaction / complex






 

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