ENSG00000103056


Homo sapiens

Features
Gene ID: ENSG00000103056
  
Biological name :SMPD3
  
Synonyms : Q9NY59 / SMPD3 / sphingomyelin phosphodiesterase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 68358325
Gene end: 68448688
  
Corresponding Affymetrix probe sets: 219695_at (Human Genome U133 Plus 2.0 Array)   231732_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455955
Ensembl peptide - ENSP00000457422
Ensembl peptide - ENSP00000459317
Ensembl peptide - ENSP00000219334
Ensembl peptide - ENSP00000457236
NCBI entrez gene - 55512     See in Manteia.
OMIM - 605777
RefSeq - XM_017023408
RefSeq - XM_011523208
RefSeq - XM_011523209
RefSeq - XM_017023405
RefSeq - XM_017023406
RefSeq - XM_017023407
RefSeq - NM_018667
RefSeq - XM_005256031
RefSeq - XM_005256032
RefSeq - XM_011523207
RefSeq Peptide - NP_061137
swissprot - H3BTM0
swissprot - I3L228
swissprot - H3BS51
swissprot - Q9NY59
Ensembl - ENSG00000103056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpd3ENSDARG00000098226Danio rerio
 SMPD3ENSGALG00000034950Gallus gallus
 Smpd3ENSMUSG00000031906Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006684 sphingomyelin metabolic process IEA
 biological_processGO:0006685 sphingomyelin catabolic process TAS
 biological_processGO:0006687 glycosphingolipid metabolic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030072 peptide hormone secretion IEA
 biological_processGO:1903543 positive regulation of exosomal secretion ISS
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process TAS
 cellular_componentGO:0000137 Golgi cis cisterna IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000035681 NSMAF / Q92636 / neutral sphingomyelinase activation associated factor  / reaction / complex
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000204628 RACK1 / P63244 / receptor for activated C kinase 1  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction






 

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