ENSG00000204628


Homo sapiens

Features
Gene ID: ENSG00000204628
  
Biological name :RACK1
  
Synonyms : P63244 / RACK1 / receptor for activated C kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.3
Gene start: 181236909
Gene end: 181248096
  
Corresponding Affymetrix probe sets: 200651_at (Human Genome U133 Plus 2.0 Array)   222034_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422768
Ensembl peptide - ENSP00000424237
Ensembl peptide - ENSP00000424654
Ensembl peptide - ENSP00000424760
Ensembl peptide - ENSP00000425008
Ensembl peptide - ENSP00000426046
Ensembl peptide - ENSP00000426101
Ensembl peptide - ENSP00000426111
Ensembl peptide - ENSP00000426270
Ensembl peptide - ENSP00000426708
Ensembl peptide - ENSP00000426909
Ensembl peptide - ENSP00000426960
Ensembl peptide - ENSP00000427677
Ensembl peptide - ENSP00000486170
Ensembl peptide - ENSP00000422029
Ensembl peptide - ENSP00000422198
Ensembl peptide - ENSP00000422316
Ensembl peptide - ENSP00000423569
Ensembl peptide - ENSP00000366013
Ensembl peptide - ENSP00000420936
Ensembl peptide - ENSP00000421356
Ensembl peptide - ENSP00000421416
Ensembl peptide - ENSP00000421838
NCBI entrez gene - 10399     See in Manteia.
OMIM - 176981
RefSeq - NM_006098
RefSeq Peptide - NP_006089
swissprot - P63244
swissprot - D6R909
swissprot - D6R9L0
swissprot - D6R9Z1
swissprot - D6RAC2
swissprot - D6RAU2
swissprot - D6RBD0
swissprot - D6RDI0
swissprot - D6REE5
swissprot - D6RF23
swissprot - D6RFX4
swissprot - D6RFZ9
swissprot - D6RGK8
swissprot - D6RHH4
swissprot - D6RHJ5
swissprot - E9KL35
swissprot - E9PD14
swissprot - H0Y8R5
swissprot - H0Y8W2
swissprot - H0Y9P0
swissprot - H0YAF8
swissprot - H0YAM7
swissprot - J3KPE3
Ensembl - ENSG00000204628
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rack1ENSDARG00000041619Danio rerio
 GNB2L1ENSGALG00000000122Gallus gallus
 Rack1ENSMUSG00000020372Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0017148 negative regulation of translation ISS
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030822 obsolete positive regulation of cAMP catabolic process IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0032464 positive regulation of protein homooligomerization IMP
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042998 positive regulation of Golgi to plasma membrane protein transport IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0051302 regulation of cell division ISS
 biological_processGO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity IMP
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0072344 rescue of stalled ribosome IMP
 biological_processGO:1900102 negative regulation of endoplasmic reticulum unfolded protein response TAS
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IGI
 biological_processGO:2000114 regulation of establishment of cell polarity ISS
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process TAS
 biological_processGO:2000543 positive regulation of gastrulation ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015935 small ribosomal subunit ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005102 signaling receptor binding NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008200 ion channel inhibitor activity ISS
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IMP
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0030292 protein tyrosine kinase inhibitor activity IDA
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IDA
 molecular_functionGO:0032947 protein-containing complex scaffold activity TAS
 molecular_functionGO:0035591 signaling adaptor activity IMP
 molecular_functionGO:0042169 SH2 domain binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043022 ribosome binding IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000035681 NSMAF / Q92636 / neutral sphingomyelinase activation associated factor  / reaction / complex
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000135587 SMPD2 / O60906 / sphingomyelin phosphodiesterase 2  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000103056 SMPD3 / Q9NY59 / sphingomyelin phosphodiesterase 3  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex






 

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