ENSGALG00000000122


Gallus gallus

Features
Gene ID: ENSGALG00000000122
  
Biological name :GNB2L1
  
Synonyms : GNB2L1 / P63247 / Receptor of activated protein C kinase 1
  
Possible biological names infered from orthology : P63244 / P68040 / RACK1 / receptor for activated C kinase 1 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed
  
Species: Gallus gallus
  
Chr. number: 16
Strand: 1
Band:
Gene start: 153731
Gene end: 157612
  
Corresponding Affymetrix probe sets: Gga.4181.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000170
Ensembl peptide - ENSGALP00000063475
Ensembl peptide - ENSGALP00000060527
Ensembl peptide - ENSGALP00000060360
Ensembl peptide - ENSGALP00000060007
Ensembl peptide - ENSGALP00000058988
Ensembl peptide - ENSGALP00000058833
Ensembl peptide - ENSGALP00000051984
NCBI entrez gene - 417044     See in Manteia.
RefSeq - NM_001004378
RefSeq Peptide - NP_001004378
swissprot - A0A1L1RNJ4
swissprot - A0A1L1RMJ5
swissprot - A0A1L1RJR1
swissprot - A0A1L1RJA4
swissprot - A0A1I7Q3Y2
swissprot - A0A1D5PGR1
swissprot - E6N1V8
swissprot - P63247
swissprot - A0A1L1RXA2
Ensembl - ENSGALG00000000122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rack1ENSDARG00000041619Danio rerio
 RACK1ENSG00000204628Homo sapiens
 Rack1ENSMUSG00000020372Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030822 obsolete positive regulation of cAMP catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042998 positive regulation of Golgi to plasma membrane protein transport IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0051302 regulation of cell division ISS
 biological_processGO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072344 rescue of stalled ribosome ISS
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IEA
 biological_processGO:2000114 regulation of establishment of cell polarity ISS
 biological_processGO:2000543 positive regulation of gastrulation ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0008200 ion channel inhibitor activity IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030292 protein tyrosine kinase inhibitor activity IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000034950 SMPD3 / sphingomyelin phosphodiesterase 3 / Q9JJY3* / Q9NY59* / sphingomyelin phosphodiesterase 3, neutral*  / reaction / complex
 ENSGALG00000033245 SMPD2 / sphingomyelin phosphodiesterase 2 / O60906* / O70572* / sphingomyelin phosphodiesterase 2, neutral*  / complex / reaction
 ENSGALG00000038838 NSMAF / neutral sphingomyelinase activation associated factor / O35242* / Q92636* / neutral sphingomyelinase (N-SMase) activation associated factor*  / complex






 

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