ENSDARG00000041619


Danio rerio

Features
Gene ID: ENSDARG00000041619
  
Biological name :rack1
  
Synonyms : O42248 / rack1 / receptor for activated C kinase 1
  
Possible biological names infered from orthology : P63244 / P68040 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 6946482
Gene end: 6953765
  
Corresponding Affymetrix probe sets: Dr.1368.1.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000061000
Ensembl peptide - ENSDARP00000133843
NCBI entrez gene - 30722     See in Manteia.
swissprot - A0A0R4IJ56
swissprot - O42248
ZFIN ID - ZDB-GENE-990415-89
Ensembl - ENSDARG00000041619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNB2L1ENSGALG00000000122Gallus gallus
 RACK1ENSG00000204628Homo sapiens
 Rack1ENSMUSG00000020372Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0051302 regulation of cell division IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 biological_processGO:2000543 positive regulation of gastrulation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005840 ribosome IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle distended , abnormal
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 ZFA:0000135 notochord notochord increased width , abnormal
notochord undulate , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism decreased length , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased functionality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000051920 nsmaf / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / complex / reaction
 ENSDARG00000040523 smpd2a / sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase) / SMPD2* / O60906* / sphingomyelin phosphodiesterase 2*  / complex / reaction
 ENSDARG00000052701 smpd2b / sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase) / SMPD2* / O70572* / O60906* / sphingomyelin phosphodiesterase 2* / sphingomyelin phosphodiesterase ...  / reaction / complex
 ENSDARG00000098226 smpd3 / sphingomyelin phosphodiesterase 3, neutral / Q9JJY3* / Q9NY59* / sphingomyelin phosphodiesterase 3*  / complex / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction






 

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