ENSDARG00000018569


Danio rerio

Features
Gene ID: ENSDARG00000018569
  
Biological name :tnfrsf1a
  
Synonyms : tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a
  
Possible biological names infered from orthology : P19438 / P25118 / TNF receptor superfamily member 1A
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 17060758
Gene end: 17072561
  
Corresponding Affymetrix probe sets: DrAffx.2.55.S1_at (Zebrafish Array)   NM_213190_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011163
Ensembl peptide - ENSDARP00000143967
NCBI entrez gene - 406471     See in Manteia.
RefSeq - NM_213190
RefSeq Peptide - NP_998355
swissprot - F1QQS0
ZFIN ID - ZDB-GENE-040426-2252
Ensembl - ENSDARG00000018569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFRSF1AENSGALG00000039461Gallus gallus
 P19438ENSG00000067182Homo sapiens
 P25118ENSMUSG00000030341Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-112c15.8 / Q93038* / TNFRSF25* / TNF receptor superfamily member 25* / tumor necrosis factor receptor superfamily, member 25*ENSDARG0000008986816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR033994  Tumor necrosis factor receptor 1A, death domain
 IPR033995  Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002631 regulation of granuloma formation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
Show

 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism decreased life span , exacerbated
Show

 ZFA:0001269 regenerating fin regenerating fin macrophage decreased amount , abnormal
regenerating fin decreased length , abnormal
Show

 ZFA:0001270 blastema blastema cell proliferation decreased occurrence , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
macrophage immune response process quality , abnormal
macrophage response to bacterium process quality , abnormal
Show

 ZFA:0009327 neutrophil neutrophil response to bacterium process quality , abnormal
neutrophil immune response process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000098226 smpd3 / sphingomyelin phosphodiesterase 3, neutral / Q9JJY3* / Q9NY59* / sphingomyelin phosphodiesterase 3*  / reaction / complex
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / reaction / complex
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / reaction / complex
 ENSDARG00000051920 nsmaf / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / reaction / complex
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex
 ENSDARG00000052701 smpd2b / sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase) / SMPD2* / O70572* / O60906* / sphingomyelin phosphodiesterase 2* / sphingomyelin phosphodiesterase ...  / complex / reaction
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / complex / reaction
 ENSDARG00000040523 smpd2a / sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase) / SMPD2* / O60906* / sphingomyelin phosphodiesterase 2*  / complex / reaction
 ENSDARG00000043179 bag4 / BCL2 associated athanogene 4 / O95429* / Q8CI61* / BAG family molecular chaperone regulator 4 *  / complex
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / reaction / complex






 

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